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首页> 外文期刊>Forensic toxicology >Identification and quantitation of N,alpha-diethylphenethylamine in preworkout supplements sold via the Internet
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Identification and quantitation of N,alpha-diethylphenethylamine in preworkout supplements sold via the Internet

机译：通过互联网销售的锻炼前补充品中N，α-二乙基苯乙胺的鉴定和定量

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Shortly after we reported the seizure of the amphetamine derivative N,alpha-diethylphenethylamine (NA-DEP) as bulk powder, we have identified NADEP in preworkout supplements branded as "Craze" and sold via the Internet. A gas chromatography-mass spectrometry method was validated and used to quantitate NADEP in the supplements. The authentic NADEP sample of the previous study was used as the reference standard for quantitative analysis after purity assay using quantitative nuclear magnetic resonance spectroscopy. Using these methods, NADEP concentrations in two Craze supplements (Berry Lemonade Flavor and Candy Grape Flavor) were quanti-tated as 0.40 and 0.44 %, respectively. With the label suggesting a serving size of 5.3-5.8 g, this was equivalent to about 23 mg of NADEP. NADEP was patented in 1988 by Knoll Pharmaceuticals with claims of psychoactive effects (e.g., cognitive enhancement and pain tolerance). For unknown reasons, the compound was never developed into a medicine, and important data about its effects and risks are lacking. Nevertheless, the patent suggested an intended oral dose range of 10-150 mg with a target of 30 mg. Therefore, it could be assumed that NADEP was added to the supplements intentionally for its pharmacological effects without adequate labeling. Because NADEP is a structural analog of methamphetamine in which the two methyl groups are only replaced by ethyl groups, it is possible that the toxicity of NADEP is similar to that ofmethamphetamine. Thus, supplements containing NADEP should be removed from the market immediately. In countries where NADEP is not regulated as a controlled substance, it should be enforced under the Medicines Act.
机译：在我们报告缉获了作为散装粉末的苯丙胺衍生物N，α-二乙基苯乙胺（NA-DEP）不久后，我们在预锻炼补品中标识为“ Craze”的NADEP并通过互联网出售。气相色谱-质谱法经验证并用于定量补充剂中的NADEP。使用定量核磁共振波谱进行纯度测定后，将先前研究的真实NADEP样品用作定量分析的参考标准。使用这些方法，将两种Craze补充剂（浆果柠檬水味和糖果葡萄味）中的NADEP浓度分别定为0.40％和0.44％。标签表明每份食用量为5.3-5.8克，相当于约23毫克NADEP。 NADEP在1988年由Knoll Pharmaceuticals申请了专利，声称具有精神活性（例如，认知增强和疼痛耐受性）。由于未知原因，该化合物从未开发成药物，并且缺乏有关其作用和风险的重要数据。但是，该专利建议口服剂量范围为10-150 mg，目标剂量为30 mg。因此，可以假设由于其药理作用而没有适当标记的情况下有意将NADEP添加到补品中。由于NADEP是甲基苯丙胺的结构类似物，其中两个甲基仅被乙基取代，因此NADEP的毒性可能与甲基苯丙胺相似。因此，应立即将含有NADEP的补品从市场上删除。在未将NADEP管制为受控物质的国家，应根据《药品法》对其进行强制执行。

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