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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Plasma constituents and mortality in rat pups given chronic insulin via injection, pellet, or osmotic minipump.
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Plasma constituents and mortality in rat pups given chronic insulin via injection, pellet, or osmotic minipump.

机译：通过注射，沉淀或渗透性微型泵给予慢性胰岛素的大鼠幼仔的血浆成分和死亡率。

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摘要

Two studies compared the glucose responses of 9-day-old rats given subcutaneous insulin, either continuously or via daily injection, for 10 days. In Experiment 1, implanted pellets released a total of 0, 1.9, or 5.7 U insulin/kg the first 24 h. Injected doses were larger, 0 or 8 U/kg. Injections caused no deaths, but insulin-releasing pellets caused high mortality within 24 h. Pups surviving the pellets were normoglycemic by treatment day 8. In Experiment 2, pups received 0.184 U of insulin daily, approximately 8 U/kg at 9 days, via either injection or osmotic minipump. All pups survived. Injected pups were hypoglycemic 2 h postinjection through treatment day 10, whereas pups with insulin minipumps were normoglycemic by day 5. Insulin injections, but not minipumps, lowered plasma triglycerides on day 10. To examine age differences in response to insulin, additional pups and adults received daily injections of 0 or 8 U/kg for 10 days. All survived. Insulin lowered plasma glucose more in pups than in adults and reduced triglycerides in pups but not in adults. The rapid development of normoglycemia in pups with insulin minipumps, compared with pups injected daily with the same dose, suggests that continuous early insulin may produce insulin resistance.
机译：两项研究比较了连续10天或每天注射皮下胰岛素的9日龄大鼠的葡萄糖反应。在实验1中，植入的药丸在最初的24小时内总共释放了0、1.9或5.7 U胰岛素/ kg。注射剂量较大，为0或8 U / kg。注射没有导致死亡，但是释放胰岛素的小丸在24小时内导致了很高的死亡率。存活至沉淀的幼犬在治疗第8天时血糖正常。在实验2中，幼犬通过注射或渗透性微型泵每天接受0.184 U的胰岛素，约在9天时约为8 U / kg。所有幼崽都存活了下来。在第10天的治疗后第2天，注射的幼犬降血糖，而到第5天，带有胰岛素微型泵的幼犬降血糖正常。在第10天，胰岛素注射而非微型泵降低了血浆甘油三酸酯。要检查对胰岛素，其他幼崽和成年犬的年龄差异每天接受0或8 U / kg的注射，持续10天。全部幸存。胰岛素降低了幼犬的血浆葡萄糖水平，使成年幼犬的甘油三酸酯降低，但成年后却没有。与每天注射相同剂量的幼犬相比，使用小型胰岛素的幼犬体内正常血糖的迅速发展表明，持续的早期胰岛素可能产生胰岛素抵抗。

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