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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Relaxation response of abdominal aorta to androgens in orchidectomised Sprague-Dawley rats fed a high-salt diet
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Relaxation response of abdominal aorta to androgens in orchidectomised Sprague-Dawley rats fed a high-salt diet

机译:饲喂高盐饮食的经去睾丸的Sprague-Dawley大鼠的腹主动脉对雄激素的松弛反应

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摘要

Previous studies have demonstrated the acute relaxant effects of androgens on normal arterial beds, but not on any with underlying or induced pathologies. This study investigated whether the status of the gonads affects the direct actions of androgens on isolated abdominal aorta from male Sprague-Dawley rats fed a high-salt diet. A high-salt diet reduced the relaxation response to exogenous testosterone, but not to dehydroepiandrosterone (DHEA). Orchidectomy reduced the relaxation response to both testosterone and DHEA, while testosterone replacement restored the acute vasorelaxant effect of testosterone and DHEA in both normal and high-salt diet fed rats. Gonadal status appears to be important in the acute vasorelaxant effect of androgens.
机译:先前的研究表明,雄激素对正常动脉床具有急性松弛作用,但对任何潜在或诱发的病状均不起作用。这项研究调查了性腺的状况是否影响雄激素对高盐饮食的雄性Sprague-Dawley大鼠离体腹主动脉的直接作用。高盐饮食会降低对外源睾丸激素的松弛反应,但不能降低对脱氢表雄酮(DHEA)的松弛反应。睾丸切除术降低了对睾丸激素和DHEA的松弛反应,而在正常和高盐饮食喂养的大鼠中,睾丸激素的替代恢复了睾丸激素和DHEA的急性血管舒张作用。性腺状态在雄激素的急性血管舒张作用中似乎很重要。

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