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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Intravenous lipid composition affects hypoxic pulmonary vasoconstriction in the newborn piglet.
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Intravenous lipid composition affects hypoxic pulmonary vasoconstriction in the newborn piglet.

机译：静脉血脂成分影响新生仔猪缺氧性肺血管收缩。

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摘要

To examine the effects of altering the fatty acid (FA) composition of intravenous (IV) lipid emulsions on pulmonary vascular resistance (PVR) and thromboxane production, we studied three groups of newborn piglets after three days of either sow's milk (milk), or total parenteral nutrition (TPN) with either iv soy bean oil (SBO, 52% n-6 and 8% n-3 FA) or fish oil (FO, 5% n-6 and 51% n-3 FA) emulsions. At baseline, and during hypoxia at 20 min and 2 h, cardiac output (Q) was measured, PVR calculated and plasma levels of a prostacyclin metabolite (6-keto-PgF1alpha) and thromboxane B2 (TxB2) were measured. Fatty acid composition of the lung phospholipids was analyzed. There was an exaggerated increase in PVR and decrease in Q during prolonged hypoxia in the TPN-SBO group as compared with the other two groups. There was no difference in PVR and Q between the milk and TPN-FO groups. FA of lung phospholipids reflected the high dietary level of long chain n-3 FA in the TPN-FO group. However, no differences in plasma levels of 6-keto-PgF1alpha or TxB2 were found. Intravenous emulsions made from SBO reduced cardiac output and increased pulmonary vascular resistance in the hypoxic newborn piglet, whereas iv FO emulsions did not. When subjects with pulmonary hypertension are receiving TPN iv SBO may be detrimental; iv FO may be beneficial, giving similar responses as in a milk-fed subject.
机译：为了研究改变静脉内（IV）脂质乳剂的脂肪酸（FA）组成对肺血管阻力（PVR）和血栓烷生成的影响，我们研究了三组母猪在母乳或牛奶三天后或静脉注射大豆油（SBO，52％n-6和8％n-3 FA）或鱼油（FO，5％n-6和51％n-3 FA）乳状液的总肠胃外营养（TPN）。在基线以及缺氧20分钟和2小时的过程中，测量心输出量（Q），计算PVR并测量血浆前列环素代谢物（6-keto-PgF1alpha）和血栓烷B2（TxB2）的水平。分析了肺磷脂的脂肪酸组成。与其他两组相比，TPN-SBO组在长时间缺氧时PVR升高，Q降低。牛奶和TPN-FO组之间的PVR和Q没有差异。 TPN-FO组的肺磷脂FA反映了长链n-3 FA的高饮食水平。但是，没有发现血浆中6-酮-PgF1alpha或TxB2的差异。用SBO制成的静脉乳剂可降低缺氧新生仔猪的心输出量并增加其肺血管阻力，而iv FO乳剂则不能。当肺动脉高压患者接受TPN静脉注射SBO可能有害; iv FO可能是有益的，给予与牛奶喂养受试者相似的反应。

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