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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations.
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Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations.

机译：加拿大土著印度人和因纽特人群体中的细胞色素P4502C9（CYP2C9）等位基因频率。

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摘要

CYP2C9 is the major P450 2C enzyme in human liver and contributes to the metabolism of a number of clinically important substrate drugs. This polymorphically expressed enzyme has been studied in Caucasian, Asian, and to some extent in African American populations, but little is known about the genetic variation in Native American populations. We therefore determined the 2C9*2 (Arg144Cys) and 2C9*3 (Ile359Leu) allele frequencies in 153 Native Canadian Indian (CNI) and 151 Inuit subjects by PCR-RFLP techniques. We also present genotyping data for two reference populations, 325 Caucasian (white North American) and 102 Chinese subjects. Genotyping analysis did not reveal any 2C9*4 alleles in the CNI, Inuit, Caucasian, or Chinese individuals. The 2C9*2 allele appears to be absent in Chinese and Inuit populations, but was present in CNI and Caucasian subjects at frequencies of 0.03 and 0.08-0.15, respectively. The 2C9*3 allele was not detected in the Inuit group, but occured in the CNI group (f = 0.06) at a frequency comparable to that of other ethnic groups. This group of Inuit individuals are the first population in which no 2C9*2 or *3 alleles have been detected so far. Therefore, these alleles may be extremely rare or absent, and unless other novel polymorphisms exist in this Inuit group one would not anticipate any CYP2C9 poor metabolizer subjects among this population.
机译：CYP2C9是人类肝脏中主要的P450 2C酶，并有助于许多临床上重要的底物药物的代谢。已经在高加索人，亚洲人和某种程度上在非裔美国人群体中研究了这种多态表达的酶，但对美洲原住民群体的遗传变异了解甚少。因此，我们通过PCR-RFLP技术确定了153名加拿大土著印第安人（CNI）和151名因纽特人受试者中的2C9 * 2（Arg144Cys）和2C9 * 3（Ile359Leu）等位基因频率。我们还提供了两个参考人群（325名白种人（北美白人）和102名中国受试者）的基因分型数据。基因分型分析未在CNI，因纽特人，高加索人或中国人中发现任何2C9 * 4等位基因。 2C9 * 2等位基因在中国和因纽特人群体中似乎不存在，但在CNI和高加索人受试者中分别以0.03和0.08-0.15的频率出现。在因纽特人组中未检测到2C9 * 3等位基因，但在CNI组中出现了（f = 0.06），其发生频率与其他种族相当。这组因纽特人是迄今为止尚未发现2C9 * 2或* 3等位基因的第一批人群。因此，这些等位基因可能极为罕见或不存在，除非在此因纽特人组中存在其他新颖的多态性，否则不会期望该人群中有任何CYP2C9弱代谢者。

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