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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Neutrophil response to prolonged exercise in immune-competent and RAG2/gamma c null mice.
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Neutrophil response to prolonged exercise in immune-competent and RAG2/gamma c null mice.

机译：中性粒细胞对免疫能力强和RAG2 /γc无效小鼠长时间运动的反应。

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The two aims of this study were (i) to compare the effects of prolonged exercise on circulating neutrophil number and muscle myeloperoxidase (MPO) activity between RAG2/gamma c null and immune-competent mice, and (ii) to evaluate the general suitability of the lymphocyte-deficient RAG2/gamma c null strain for use in exercise models of immune regulation. RAG2/gamma c null (male and female) and C57BL/6 (congenic immune-competent, male) mice were assigned to either control (C) or treadmill exercise (EX, 22 m/min, 90 min, 6% grade) groups. EX mice were killed immediately (EX0) or 24 h (EX24) after exercise. RAG2/gamma c null males had significantly (P < 0.05) fewer circulating CD45+ cells and higher %CD45+ neutrophils than did C57BL/6 males, independent of exercise. A significant interaction was observed for the effects of exercise and gender on %CD45+ neutrophils in the blood. At EX24, gastrocnemius (Gastroc) MPO significantly increased in EX mice. Gastroc MPO activity was 44% and 35% higher in RAG2/gamma c null vs. C57BL/6 males, and in female vs. male RAG2/gamma c null mice, respectively. Heart MPO activity did not differ between strains or among treatments. We concluded that the Rag2/gamma c null strain is a suitable model for future investigations on immune regulation following acute exercise stress.
机译：这项研究的两个目的是（i）比较长时间运动对RAG2 /γc无效小鼠和具有免疫能力的小鼠之间的循环中性粒细胞数和肌肉髓过氧化物酶（MPO）活性的影响，以及（ii）评估一般性适应症。用于免疫调节运动模型的淋巴细胞缺陷型RAG2 /γc无效菌株。将RAG2 / gamma c null（雄性和雌性）和C57BL / 6（具有转基因免疫能力的雄性）小鼠分为对照组（C）或跑步机运动（EX，22 m / min，90 min，6％级） 。运动后立即（EX0）或24小时（EX24）杀死EX小鼠。与运动无关，与C57BL / 6雄性相比，RAG2 / gamma c无性雄性的循环CD45 +细胞显着少（P <0.05），而CD45 +中性粒细胞百分比更高。观察到运动和性别对血液中CD45 +中性粒细胞的影响存在显着相互作用。在EX24，腓肠肌（Gastroc）MPO在EX小鼠中显着增加。与C57BL / 6雄性相比，RAG2 / gamma c null小鼠的胃MPO活性分别高44％和35％，在雌性与雄性RAG2 / gamma c null小鼠中，其GPO活性分别高。品系之间或治疗之间的心脏MPO活性没有差异。我们得出的结论是，Rag2 /γc null毒株是适合急性运动应激后未来免疫调节研究的合适模型。

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