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首页> 外文期刊>Biochemical Pharmacology >Effect of DHEA on endocrine functions of adipose tissue, the involvement of PPAR gamma.
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Effect of DHEA on endocrine functions of adipose tissue, the involvement of PPAR gamma.

机译：DHEA对脂肪组织内分泌功能的影响，PPARγ的参与。

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摘要

Dehydroepiandrosterone (DHEA), an adrenal steroid, is known to decrease body fat. Thus, it may also alter the endocrine functions of adipose tissue. The aim of this study was to determine if administration of DHEA might influence adiponectin gene expression and secretion from adipose tissue. We demonstrate here the inducing effect of exogenously administered DHEA on adiponectin gene expression in epididymal WAT and adiponectin levels in serum of rats fed a DHEA-containing diet (0.6%, w/w) for 2 weeks, accompanied by a reduction in epididymal adipose tissue mass. A corresponding increase in peroxisome proliferator-activated receptor gamma (PPAR(gamma)) mRNA expression suggests that PPAR(gamma) may be involved in the up-regulation of adiponectin gene expression after DHEA treatment. The presented observations indicate that the positive effects of DHEA, which seems to play a protective role against insulin resistance and atherosclerosis, may be in fact indirect and due to up-regulation of adiponectin geneexpression and stimulation of adiponectin secretion from adipose tissue.
机译：肾上腺类固醇脱氢表雄酮（DHEA）可以减少体内脂肪。因此，它也可能改变脂肪组织的内分泌功能。这项研究的目的是确定DHEA的施用是否会影响脂联素基因的表达和脂肪组织的分泌。我们在这里证明了外源性DHEA对附睾WAT和脂联素在大鼠血清中的脂联素基因表达的诱导作用，该大鼠喂食含DHEA（0.6％，w / w）2周的大鼠，伴随着附睾脂肪组织的减少质量过氧化物酶体增殖物激活的受体γ（PPAR（γ））mRNA表达相应增加表明，DHEA处理后，PPAR（γ）可能参与脂联素基因表达的上调。提出的观察结果表明，DHEA的积极作用似乎是间接的，并且可能是由于脂联素基因表达的上调和刺激脂肪组织分泌脂联素引起的，而DHEA似乎在抵抗胰岛素抵抗和动脉粥样硬化中起到了保护作用。

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