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Molecular Basis for Cancer Chemoprevention by Green Tea Polyphenol EGCG

机译：绿茶多酚EGCG预防癌症的分子基础

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摘要

For the past two decades, many researchers have been investigating the potential cancer-preventive and therapeutic effects of green tea. (-)-Epigallocatechin-3-O-gallate (EGCG) has been shown to be the most active and major polyphenolic compound fromgreen tea. The mechanisms of action of EGCG have been extensively investigated. However, the mechanisms for the cancer-preventive activity of EGCG are not completely characterized and many features remain to be elucidated. Recently, we have identified the 67-kDa laminin receptor (67LR) as a cell surface EGCG receptor that confers EGCG responsiveness to many cancer cells at physiological concentrations. This article reviews some of the reported mechanisms and possible targets for the action of EGCG. We especially focus on the current understanding of the signaling pathway for physiologically relevant EGCG through the 67LR for cancer prevention. Our data shed new light on the molecular basis for the cancer-preventive activity of EGCG in vivo and helps in the design of new strategies to prevent cancer.
机译：在过去的二十年中，许多研究人员一直在研究绿茶对癌症的潜在预防和治疗作用。 （-）-Epigallocatechin-3-O-gallate（EGCG）已被证明是绿茶中活性最高，最主要的多酚化合物。 EGCG的作用机理已被广泛研究。然而，EGCG的预防癌症活性的机制尚未完全表征，许多功能仍有待阐明。最近，我们已经确定67-kDa层粘连蛋白受体（67LR）是一种细胞表面EGCG受体，可在生理浓度下赋予EGCG对许多癌细胞的响应能力。本文回顾了一些已报道的EGCG作用机制和可能的靶标。我们特别关注当前对通过67LR预防癌症的生理相关EGCG信号通路的了解。我们的数据在分子基础上为EGCG体内的癌症预防活性提供了新的思路，并有助于设计预防癌症的新策略。

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