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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >The relaxant effect of nociceptin on porcine coronary arterial ring segments.
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The relaxant effect of nociceptin on porcine coronary arterial ring segments.

机译：伤害感受肽对猪冠状动脉环段的松弛作用。

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摘要

Nociceptin (NC), alias orphanin FQ, has been identified as the endogenous ligand of the opioid receptor-like 1 receptor (ORL1). The purpose of this study was to assess the effect of nociceptin on porcine coronary arteries and to investigate the mechanism of its action, if any. Rings of coronary arteries from porcine hearts were suspended in baths containing Krebs solution, and isometric tension was measured. The response to nociceptin (10(-1)2-10(-5) mol/L) was investigated in porcine coronary arterial rings and also in such rings contracted with prostaglandin F2alpha (PGF2alpha). The effects of endothelium, nitroxide (NO), methylene blue, cyclic GMP (cGMP), naloxone, [Nphe1]NC(1-13)NH2, and propranolol on nociceptin-induced relaxation were also assessed. Our study showed nociceptin relaxed the porcine coronary arterial rings and inhibited the vasocontractivity to PGF2alpha. The relaxing response of nociceptin in coronary arteries was significantly reduced by removal of endothelium and by the presence of L-NNA, cGMP, and [Nphe1]NC(1-13)NH2, the selective nociceptin receptor antagonist, but not by naloxone, the nonselestive opioid receptor blocker or propranolol, which blocks the adrenergic beta-receptor. Our results suggest that nociceptin induces relaxation of isolated coronary artery through NO, cGMP, and ORL1.
机译：Nociceptin（NC），别名孤儿蛋白FQ，已被确定为类阿片受体样1受体（ORL1）的内源性配体。这项研究的目的是评估伤害感受肽对猪冠状动脉的作用，并研究其作用机理（如有）。将来自猪心脏的冠状动脉环悬挂在含有Krebs溶液的浴中，并测量等轴测张力。在猪冠状动脉环以及与前列腺素F2alpha（PGF2alpha）收缩的这种环中，研究了对伤害感受素（10（-1）2-10（-5）mol / L）的反应。还评估了内皮，一氧化氮（NO），亚甲基蓝，环状GMP（cGMP），纳洛酮，[Nphe1] NC（1-13）NH2和普萘洛尔对伤害感受素诱导的松弛的影响。我们的研究表明，伤害感受肽可以放松猪冠状动脉环并抑制对PGF2α的血管收缩。通过去除内皮以及存在选择性伤害感受器受体拮抗剂[Nphe1] NC（1-13）NH2，L-NNA，cGMP和[Nphe1] NC（1-13）NH2的存在，可以显着降低伤害感受器在冠状动脉中的舒张反应，但纳洛酮却不能。非选择性阿片受体阻滞剂或普萘洛尔，可阻断肾上腺素能β受体。我们的结果表明，伤害感受肽可通过NO，cGMP和ORL1诱导离体冠状动脉舒张。

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