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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Endoplasmic reticulum proteins in cardiac development and dysfunction.
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Endoplasmic reticulum proteins in cardiac development and dysfunction.

机译：内质网蛋白在心脏发育和功能障碍。

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摘要

An understanding of cardiac pathologies and the molecular mechanisms thereof is essential for the development of therapies for cardiovascular disease, a common cause of death in Western societies. Investigations into heart diseases have shown that the endoplasmic reticulum and its diverse functions may lie at the center of many cardiac pathologies. Animal models have demonstrated that in numerous cases, faulty endoplasmic reticulum activity is manifested in defective cardiogenesis or impaired heart function. These findings suggest that the endoplasmic and sarcoplasmic reticulum membranes may represent functionally independent organelles responsible for specialized functions in the heart. This review addresses the molecular pathways linking endoplasmic reticulum function and malfunction with impaired cardiac phenotypes. The endoplasmic reticulum affects cardiac development and function through Ca2+-dependent pathways, its catalytic role in the proper folding and targeting of membrane-bound and secretory proteins, and its response to cellular stress events, particularly hypoxic conditions. These pathways present potential novel targets for treatment of cardiac disease.
机译：对心脏病理学及其分子机制的了解对于发展心血管疾病的疗法至关重要，而心血管疾病是西方社会常见的死亡原因。对心脏病的研究表明，内质网及其多种功能可能位于许多心脏疾病的中心。动物模型已经证明，在许多情况下，有缺陷的内质网活性表现为有缺陷的心脏发生或心脏功能受损。这些发现表明，内质网和肌浆网膜可能代表负责心脏特殊功能的功能独立的细胞器。这项审查解决分子通路与内质网功能和功能障碍与心脏表型受损。内质网通过Ca 2+依赖性途径影响心脏发育和功能，其在膜结合蛋白和分泌蛋白的正确折叠和靶向中的催化作用以及对细胞应激事件（特别是低氧条件）的反应。这些途径提出了治疗心脏病的潜在新靶标。

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