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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Ameliorating effects of cloperastine on dysfunction of the urinary bladder caused by cerebral infarction in conscious rats.
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Ameliorating effects of cloperastine on dysfunction of the urinary bladder caused by cerebral infarction in conscious rats.

机译：氯吡汀对清醒大鼠脑梗塞引起的膀胱功能障碍的改善作用。

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摘要

We investigated the effects of the centrally acting antitussives dextromethorphan and cloperastine on urinary bladder dysfunction 24 h after cerebral infarction in rats using the cystometry technique. First, cystometrography was performed in conscious male Sprague-Dawley rats. Cerebral infarction was then induced by occlusion of the left middle cerebral artery. Twenty-four hours after cerebral infarction, the effect of each drug on micturition disorder was estimated for 5 parameters: bladder capacity, maximum voiding pressure, micturition latency, flow rate, and urethral resistance. Cerebral infarction markedly reduced bladder capacity, micturition latency, and flow rate and increased urethral resistance. After cerebral infarction, intravenous dosing of saline had no effect on these parameters. Dextromethorphan (20 mg/kg) and cloperastine (2.5 and 5.0 mg/kg) at antitussive effective doses significantly increased bladder capacity and micturition latency. Unlike dextromethorphan, cloperastine ameliorated decreases in flow rate and increases in urethral resistance caused by cerebral infarction. These results suggest that cloperastine may have therapeutic value for the treatment of disorders of the micturition reflex associated with cerebral infarction, and that the drug may become a base compound from which to develop more active drugs for such disorders.
机译：我们使用膀胱测压技术调查了脑梗死后24 h大鼠中枢性镇咳药右美沙芬和氯吡汀对膀胱功能障碍的影响。首先，在有意识的雄性Sprague-Dawley大鼠中进行膀胱镜描记术。然后通过阻塞左大脑中动脉诱发脑梗塞。脑梗死后二十四小时，评估了每种药物对排尿障碍的影响，涉及五个参数：膀胱容量，最大排尿压力，排尿潜伏期，流速和尿道阻力。脑梗塞明显减少了膀胱容量，排尿潜伏期和流速，并增加了尿道阻力。脑梗死后，静脉注射生理盐水对这些参数没有影响。镇咳有效剂量的右美沙芬（20 mg / kg）和氯吡汀（2.5和5.0 mg / kg）显着增加了膀胱容量和排尿潜伏期。与右美沙芬不同，氯吡汀改善的流量减少，脑梗死引起的尿道阻力增加。这些结果表明，氯培斯汀对治疗与脑梗塞有关的排尿反射疾病具有治疗价值，并且该药物可能成为基础化合物，可从中开发出用于此类疾病的更多活性药物。

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