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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Inhibitory effects of dauricine on early afterdepolarizations and L-type calcium current.
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Inhibitory effects of dauricine on early afterdepolarizations and L-type calcium current.

机译：牛磺酸对早期除极化和L型钙电流的抑制作用。

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We have previously reported that dauricine exerted antiarrhythmic effects on various experimental arrhythmias. To further clarify its mechanism, the effects of dauricine on action potential duration (APD), early afterdepolarizations (EADs), triangulation, which is defined as the repolarization time from APD at 30% level (APD30) to APD at 90% level (APD90), and L-type calcium current (I(Ca-L)) were studied using standard microelectrode techniques on rabbit papillary muscles and whole-cell patch clamp techniques on single myocytes isolated from rabbits by enzymatic digestion, respectively. Cardiac hypertrophy was induced by coarctating the abdominal aorta of rabbits. The results showed that in papillary muscles of hypertrophied rabbits, 1 micromol/L dofetilide, a selective IKr blocker, prolonged APD50 and APD90 and induced EADs (4/6, p < 0.01) with hypokalemia ([K+]o = 2.7 mmol/L). Dauricine inhibited EADs (p < 0.01) and shortened the prolonged APD (p < 0.01). In single myocytes, dauricine also inhibited EADs induced by dofetilide, hypokalemia, and hypomagnesaemia. Dauricine decreased the triangulation and reduced the peak amplitude of I(Ca-L) at all potentials tested. Dauricine shifted the steady-state activation curves to the right and steady-state inactivation curves to the left and prolonged the tau value of the recovery curve. These results suggest that dauricine inhibits EADs and this effect may be associated with its blockade of I(Ca-L).
机译：我们以前曾报道过，牛磺酸对各种实验性心律不齐具有抗心律失常作用。为了进一步阐明其机理，黄uri碱对动作电位持续时间（APD），早期去极化后（EAD），三角测量的作用，这定义为从30％的APD（APD30）到90％的APD（APD90）的复极化时间）和L型钙电流（I（Ca-L））分别在兔乳头肌上使用标准微电极技术和通过酶消化从兔分离的单个心肌上的全细胞膜片钳技术进行了研究。通过缩窄兔腹主动脉来诱发心脏肥大。结果表明，在肥大兔的乳头肌中，1μmol/ L多普利特，一种选择性IKr阻滞剂，延长的APD50和APD90以及低血钾（[K +] o = 2.7 mmol / L）诱导的EAD（4/6，p <0.01） ）。牛磺酸可抑制EADs（p <0.01）并缩短了延长的APD（p <0.01）。在单个肌细胞中，红uri碱还抑制由多非利特，低钾血症和低镁血症引起的EAD。在所有测试电势下，Dauricine都会降低三角测量并降低I（Ca-L）的峰值幅度。 Dauricine将稳态激活曲线向右移动，并将稳态灭活曲线向左移动，并延长了恢复曲线的tau值。这些结果表明，dauricine抑制EADs，这种作用可能与其对I（Ca-L）的阻断有关。

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