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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Alteration in the expression of exon IIC transcripts of brain-derived neurotrophic factor gene by simvastain in chronic mild stress in mice: a possible link with dopaminergic pathway
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Alteration in the expression of exon IIC transcripts of brain-derived neurotrophic factor gene by simvastain in chronic mild stress in mice: a possible link with dopaminergic pathway

机译：辛伐司汀对慢性轻度应激小鼠脑源性神经营养因子基因外显子IIC转录表达的改变：与多巴胺能途径的可能联系

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We have investigated the influence of dopaminergic agents on the expression of brain-derived neurotrophic factor (BDNF) gene in relation with lipid levels in chronic mild stress (CMS). Mice subjected to CMS were treated with simvastatin (10 mg/kg, per os (orally)) along with bromocriptine (2 mg/kg, intraperitoneally (ip)), levodopa (200 mg/kg, ip), or haloperidol (0.1 mg/kg, ip) for 14 days. CMS produced a decrease in sucrose intake and an increase in serum cholesterol and triglycerides levels with a decrease in high-density lipoprotein cholesterol, which were prevented by simvastatin. This was greater when it was combined with bromocriptine or levodopa. Haloperidol significantly prevented the simvastatin-induced increase in sucrose intake but not the alterations in lipids. There was an upregulation in the expression of BDNF exon-IIA and -IIB transcripts by CMS but not the exon-IIC transcripts. Simvastatin could increase expression of exon-IIC transcripts in stressed mice. This was partially increased by bromocriptine. Haloperidol significantly prevented simvastatin-induced increase in expression of BDNF exon-IIC transcripts. The results showed a positive correlation between expression of BDNF exon-IIC transcripts and sucrose intake. In conclusion, our data suggest the involvement of lipid levels and BDNF exon-IIC transcripts in CMS-induced behaviour in mice, possibly through the dopaminergic system.
机译：我们已经研究了多巴胺能药物对慢性轻度应激（CMS）中脂质水平与脑源性神经营养因子（BDNF）基因表达的影响。接受CMS的小鼠接受辛伐他汀（10 mg / kg，口服（口服）），溴隐亭（2 mg / kg，腹膜内（ip）），左旋多巴（200 mg / kg，ip）或氟哌啶醇（0.1 mg / kg，ip）14天。 CMS导致蔗糖摄入量减少，血清胆固醇和甘油三酸酯水平升高，而高密度脂蛋白胆固醇降低，辛伐他汀可以预防这种情况。当与溴隐亭或左旋多巴合用时，这种情况会更大。氟哌啶醇可显着阻止辛伐他汀引起的蔗糖摄入增加，但不能阻止脂质的改变。 CMS的BDNF外显子-IIA和-IIB转录表达上调，但外显子-IIC转录没有上调。辛伐他汀可以增加应激小鼠中外显子IIC转录物的表达。溴隐亭部分增加了这种情况。氟哌啶醇显着阻止辛伐他汀诱导的BDNF外显子-IIC转录本表达的增加。结果显示BDNF外显子-IIC转录表达与蔗糖摄入量呈正相关。总之，我们的数据表明脂质水平和BDNF外显子IIC转录物可能通过多巴胺能系统参与了CMS诱导的小鼠行为。

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