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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Recoil proton, alpha particle, and heavy ion impacts on microdosimetry and RBE of fast neutrons: analysis of kerma spectra calculated by Monte Carlo simulation.
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Recoil proton, alpha particle, and heavy ion impacts on microdosimetry and RBE of fast neutrons: analysis of kerma spectra calculated by Monte Carlo simulation.

机译：反冲质子，α粒子和重离子对快中子的微剂量和RBE的影响：通过蒙特卡洛模拟计算的比释动能谱分析。

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摘要

Fast neutrons (FN) have a higher radio-biological effectiveness (RBE) compared with photons, however the mechanism of this increase remains a controversial issue. RBE variations are seen among various FN facilities and at the same facility when different tissue depths or thicknesses of hardening filters are used. These variations lead to uncertainties in dose reporting as well as in the comparisons of clinical results. Besides radiobiology and microdosimetry, another powerful method for the characterization of FN beams is the calculation of total proton and heavy ion kerma spectra. FLUKA and MCNP Monte Carlo code were used to simulate these kerma spectra following a set of microdosimetry measurements performed at the National Accelerator Centre. The calculated spectra confirmed major classical statements: RBE increase is linked to both slow energy protons and alpha particles yielded by (n,alpha) reactions on carbon and oxygen nuclei. The slow energy protons are produced by neutrons having an energy between 10 keV and 10 MeV, while the alpha particles are produced by neutrons having an energy between 10 keV and 15 MeV. Looking at the heavy ion kerma from <15 MeV and the proton kerma from neutrons <10 MeV, it is possible to anticipate y* and RBE trends.
机译：与光子相比，快中子（FN）具有更高的放射生物有效性（RBE），但是这种增加的机制仍然是一个有争议的问题。当使用不同的组织深度或硬化过滤器的厚度时，在不同的FN设施之间以及在同一设施中，RBE会出现变化。这些差异导致剂量报告以及临床结果比较的不确定性。除了放射生物学和微剂量法外，表征FN束的另一种有效方法是计算总质子和重离子比释动能谱。在国家加速器中心进行一系列微剂量测量之后，使用FLUKA和MCNP蒙特卡罗代码来模拟这些比释动能光谱。计算得出的光谱证实了主要的经典说法：RBE的增加与碳和氧核上的（n，alpha）反应产生的慢能量质子和alpha粒子有关。慢能质子由能量在10 keV到10 MeV之间的中子产生，而α粒子由能量在10 keV到15 MeV之间的中子产生。观察来自<15 MeV的重离子比释动能和来自中子<10 MeV的质子比释动能，可以预测y *和RBE趋势。

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