Effect of human urotensin-II infusion on hemodynamics and cardiac function.

Hassan GS; Chouiali F; Saito T; Hu F; Douglas SA; Ao Z; Willette RN; Ohlstein EH; Giaid A

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Effect of human urotensin-II infusion on hemodynamics and cardiac function.

机译：人尿素II输注对血流动力学和心脏功能的影响。

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Recent studies have shown that the vasoactive peptide urotensin-II (U-II) exerts a wide range of action on the cardiovascular system of various species. In the present study, we determined the in vivo effects of U-II on basal hemodynamics and cardiac function in the anesthetized intact rat. Intravenous bolus injection of human U-II resulted in a dose-dependent decrease in mean arterial pressure and left ventricular systolic pressure. Cardiac contractility represented by +/-dP/dt was decreased after injection of U-II. However, there was no significant change in heart rate or diastolic pressure. The present study suggests that upregulation of myocardial U-II may contribute to impaired myocardial function in disease conditions such as congestive heart failure.

机译：最近的研究表明，血管活性肽urotensin-II（U-II）对各种物种的心血管系统具有广泛的作用。在本研究中，我们确定了U-II对麻醉的完整大鼠的基础血液动力学和心脏功能的体内影响。人U-II静脉推注导致平均动脉压和左心室收缩压的剂量依赖性降低。注射U-II后，以+/- dP / dt表示的心脏收缩力降低。但是，心率或舒张压没有明显变化。本研究表明，在诸如充血性心力衰竭之类的疾病中，心肌U-II的上调可能导致心肌功能受损。

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来源
《Canadian Journal of Physiology and Pharmacology》 |2003年第2期|共4页
作者
Hassan GS; Chouiali F; Saito T; Hu F; Douglas SA; Ao Z; Willette RN; Ohlstein EH; Giaid A;
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正文语种 eng
中图分类人体生理学;药理学;生理学;药学;
关键词
Unit; Cardio-; physiological aspects; Human; Hemodynamics; 血液动力学;

机译：Unit;Cardio-;physiological aspects;Human;Hemodynamics;血液动力学;

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1. Effect of human urotensin-II infusion on hemodynamics and cardiac function. [J] . Hassan GS, Chouiali F, Saito T, Canadian Journal of Physiology and Pharmacology . 2003,第2期

机译：人尿素II输注对血流动力学和心脏功能的影响。
2. Immunocytochemical localization of the urotensin-II receptor, UT, to rat and human tissues: Relevance to function. [J] . Maguire JJ, Kuc RE, Kleinz MJ, Peptides: An International Journal . 2008,第5期

机译：urotensin-II受体UT对大鼠和人体组织的免疫细胞化学定位：与功能的相关性。
3. Acute hemodynamic efficacy of a 32-ml subcutaneous counterpulsation device in a calf model of diminished cardiac function. [J] . Koenig SC, Litwak KN, Giridharan GA, ASAIO journal . 2008,第6期

机译：在心功能减弱的小腿模型中，32毫升皮下反搏装置的急性血液动力学功效。
4. The effects of hypervolemia on cardiac function. A computer simulation [C] . Kong An, Bai Jing . 1997

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5. A Wearable Near-Infrared Diffuse Optical System for Monitoring in Vivo Breast Tumor Hemodynamics during Chemotherapy Infusions [D] . Teng, Fei. 2018

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6. Effects of intracoronary and intravenous amrinone infusions in patients with cardiac failure and patients with near normal cardiac function. [O] . P T Wilmshurst, D S Thompson, S M Juul, 1985

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8. Hemodynamic and ADH responses to central blood volume shifts in cardiac-denervated humans [R] . Convertino, V. A., Thompson, C. A., Benjamin, B. A., 1990

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Effect of human urotensin-II infusion on hemodynamics and cardiac function.

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