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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Antihypertensive and neuroprotective actions of pyridoxine and its derivatives
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Antihypertensive and neuroprotective actions of pyridoxine and its derivatives

机译:吡ido醇及其衍生物的抗高血压和神经保护作用

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摘要

Vitamin B-6 plays a crucial role in the nervous system as the amino acid decarboxylases involved in the synthesis of all putative neurotransmitters requires the coenzyme pyridoxal phosphate. Vitamin B-6 in its various forms has antioxidant properties. Pyridoxal phosphate has a role in regulating cellular calcium transport through both the voltage-mediated and ATP-mediated purinergic mechanisms of cellular calcium influx and, hence, has a role in the control of hypertension. Pharmacological doses of vitamin B-6 appear to decrease the high blood pressure associated with both genetic and nongenetic models of hypertension. Vitamin B-6 has a crucial role in the normal function of the central and peripheral nervous systems. It also protects against ischemia and glutamate-induced neurotoxicity.
机译:维生素B-6在神经系统中起着至关重要的作用,因为参与所有假定的神经递质合成的氨基酸脱羧酶需要辅酶吡ido醛磷酸盐。各种形式的维生素B-6具有抗氧化特性。磷酸吡rid醛通过电压介导和ATP介导的细胞钙内流嘌呤能机制,在调节细胞钙转运中发挥作用,因此在控制高血压中起作用。维生素B-6的药理剂量似乎可以降低与遗传性和非遗传性高血压模型相关的高血压。维生素B-6在中枢神经系统和周围神经系统的正常功能中起着至关重要的作用。它还可以防止缺血和谷氨酸诱导的神经毒性。

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