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首页> 外文期刊>Frontiers in neuroendocrinology >Dissection of glucocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis by gene targeting in mice
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Dissection of glucocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis by gene targeting in mice

机译：小鼠基因靶向介导的糖皮质激素受体介导的下丘脑-垂体-肾上腺轴抑制作用的解剖

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Negative feedback regulation of glucocorticoid (GC) synthesis and secretion occurs through the function of glucocorticoid receptor (GR) at sites in the hypothalamic-pituitary-adrenal (HPA) axis, as well as in brain regions such as the hippocampus, prefrontal cortex, and sympathetic nervous system. This function of GRs in negative feedback coordinates basal glucocorticoid secretion and stress-induced increases in secretion that integrate GC production with the magnitude and duration of the stressor. This review describes the effects of GR loss along major sites of negative feedback including the entire brain, the paraventricular nucleus of the hypothalamus (PVN), and the pituitary. In genetic mouse models, we evaluate circadian regulation of the HPA axis, stress-stimulated neuroendocrine response and behavioral activity, as well as the integrated response of organism metabolism. Our analysis provides information on contributions of region-specific GR-mediated negative feedback to provide insight in understanding HPA axis dysregulation and the pathogenesis of psychiatric and metabolic disorders. (C) 2014 Elsevier Inc. All rights reserved.
机译：糖皮质激素（GC）合成和分泌的负反馈调节是通过在下丘脑-垂体-肾上腺（HPA）轴上以及大脑区域（例如海马，前额叶皮层和交感神经系统。 GRs在负反馈中的这种功能可协调基础糖皮质激素的分泌和应激诱导的分泌增加，从而将GC的产生与应激源的大小和持续时间结合在一起。这篇综述描述了在负反馈的主要部位，包括整个大脑，下丘脑室旁核（PVN）和垂体，GR丧失的影响。在遗传小鼠模型中，我们评估了HPA轴的昼夜节律调节，应激刺激的神经内分泌反应和行为活动以及生物体代谢的综合反应。我们的分析提供了有关特定区域GR介导的负反馈贡献的信息，以帮助您了解HPA轴失调以及精神病和代谢病的发病机理。 （C）2014 Elsevier Inc.保留所有权利。

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