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首页> 外文期刊>Frontiers in neuroendocrinology >Menopause and Parkinson's disease. Interaction between estrogens and brain renin-angiotensin system in dopaminergic degeneration
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Menopause and Parkinson's disease. Interaction between estrogens and brain renin-angiotensin system in dopaminergic degeneration

机译：更年期和帕金森氏病。多巴胺能变性中雌激素与脑肾素-血管紧张素系统的相互作用

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The neuroprotective effects of menopausal hormonal therapy in Parkinson's disease (PD) have not yet been clarified, and it is controversial whether there is a critical period for neuroprotection. Studies in animal models and clinical and epidemiological studies indicate that estrogens induce dopaminergic neuroprotection. Recent studies suggest that inhibition of the brain renin-angiotensin system (RAS) mediates the effects of estrogens in PD models. In the substantia nigra, ovariectomy induces a decrease in levels of estrogen receptor-alpha (ER-alpha) and increases angiotensin activity, NADPH-oxidase activity and expression of neuroinflammatory markers, which are regulated by estrogen replacement therapy. There is a critical period for the neuroprotective effect of estrogen replacement therapy, and local ER-alpha and RAS play a major role. Astrocytes play a major role in ER -alpha-induced regulation of local RAS, but neurons and microglia are also involved. Interestingly, treatment with angiotensin receptor antagonists after the critical period induced neuroprotection. (C) 2016 Elsevier Inc. All rights reserved.
机译：更年期激素疗法对帕金森氏病（PD）的神经保护作用尚未阐明，是否存在神经保护的关键时期尚有争议。动物模型研究以及临床和流行病学研究表明，雌激素可诱导多巴胺能神经保护。最近的研究表明，对脑肾素-血管紧张素系统（RAS）的抑制会介导PD模型中雌激素的作用。在黑质中，卵巢切除术可降低雌激素受体α（ER-alpha）的水平，并增加血管紧张素活性，NADPH氧化酶活性和神经炎性标志物的表达，这受雌激素替代疗法的调节。雌激素替代疗法的神经保护作用有一个关键时期，而局部ER-α和RAS发挥着重要作用。星形胶质细胞在ER-α诱导的局部RAS调节中起主要作用，但神经元和小胶质细胞也参与其中。有趣的是，关键时期后用血管紧张素受体拮抗剂治疗可诱导神经保护作用。 （C）2016 Elsevier Inc.保留所有权利。

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