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Hyphal morphogenesis in Aspergillus nidulans

机译:构巢曲霉的菌丝形态发生

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The formation of hyphae that grow solely by apical extension is a denning feature of filamentous fungi. Hyphal morphogenesis involves several key steps, including the establishment and maintenance of a stable polarity axis, as well as cell division uia the deposition of septa. Several filamentous fungi have been employed in attempts to decipher the mechanisms underlying these steps. Amongst these fungi, Aspergillus nidulans has proven to be a particularly valuable model. The genetic tractability of this fungus coupled with the availability of sophisticated post-genomics resources has enabled the identification and characterization of numerous genes involved in hyphal morphogenesis. Here, we summarize current progress towards understanding the function of these genes and the mechanisms involved in polarized hyphal growth and septation in A. nidulans. We also highlight important areas for future investigation.
机译:仅通过根尖延伸生长的菌丝的形成是丝状真菌的致密特征。菌丝形态发生涉及几个关键步骤,包括建立和维持稳定的极性轴,以及通过隔膜沉积进行细胞分裂。已经尝试使用几种丝状真菌来试图破译这些步骤的机制。在这些真菌中,构巢曲霉被证明是特别有价值的模型。这种真菌的遗传易处理性,再加上复杂的后基因组学资源的可用性,使得能够鉴定和表征涉及菌丝形态发生的众多基因。在这里,我们总结了了解这些基因的功能以及参与构巢曲霉极化菌丝生长和分离的机制的最新进展。我们还重点介绍了未来调查的重要领域。

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