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首页> 外文期刊>Fungal Biology Reviews >Will fungi be the new source of the blockbuster drug taxol?
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Will fungi be the new source of the blockbuster drug taxol?

机译：真菌会成为重磅炸药紫杉醇的新来源吗？

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摘要

Taxol (paclitaxel) is widely used for the treatment of various kinds of cancers. Originally, the major source of taxol was bark of the Pacific yew tree (Taxus brevifolia). However, this proved devastating to natural populations of the trees. To protect the Pacific yew, alternatives to the use of trees are sought, One solution is the use of taxol or its precursors derived from fungi. A large number of endophytic fungi that reside within healthy plants have been reported to be taxol producers. However, fungal epiphytes, pathogens and saprophytes have also been found to produce taxol. Several strains of fungi belonging to species Metarhizium anisopliae and Cladosporium cladosporioides MD2 are very promising, producing taxol at levels up to 800 mu g/L. This review examines the potential for production of taxol from fungi. The biology of taxol synthesis in fungi and measures which may improve taxol yield are also discussed. (C) 2014 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.
机译：紫杉醇（紫杉醇）被广泛用于治疗各种癌症。最初，紫杉醇的主要来源是太平洋紫杉树的树皮（Taxus brevifolia）。然而，事实证明这对树木的自然种群是毁灭性的。为了保护太平洋紫杉，寻求使用树木的替代方法。一种解决方案是使用紫杉醇或其衍生自真菌的前体。据报道，存在于健康植物中的大量内生真菌是紫杉醇的生产者。然而，真菌附生植物，病原体和腐生植物也被发现产生紫杉醇。属于Anterhizium anisopliae和Cladosporium cladosporioides MD2物种的几种真菌菌株非常有前途，产生的紫杉酚含量高达800μg / L。这项审查审查了从真菌生产紫杉醇的潜力。还讨论了真菌中紫杉醇合成的生物学特性以及可能提高紫杉醇产量的措施。 （C）2014英国Mycological Society。由Elsevier Ltd.出版。保留所有权利。

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