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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Comparative effectiveness of carvedilol and propranolol on glycemic control and insulin resistance associated with L-thyroxin-induced hyperthyroidism--an experimental study.
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Comparative effectiveness of carvedilol and propranolol on glycemic control and insulin resistance associated with L-thyroxin-induced hyperthyroidism--an experimental study.

机译：卡维地洛和普萘洛尔对与L-甲状腺素诱发的甲状腺功能亢进有关的血糖控制和胰岛素抵抗的比较效果-实验研究。

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The present study was undertaken to investigate the effectiveness of adrenergic antagonists carvedilol and propranolol on L-thyroxin-induced cardiovascular and metabolic disturbances in rats. Treatment with L-thyroxin sodium (75 mg/kg body mass, s.c., every alternate day for 3 weeks), produced a significant increase in food and water intake, body temperature, heart rate, systolic blood pressure, along with an increase in serum T3, T4, and triglyceride levels. Besides a significant reduction in body mass, serum levels of TSH and cholesterol were also reduced following L-thyroxin treatment. Carvedilol (10 mg/kg body mass, orally) and propranolol (10 mg/kg body mass, i.p.) administered daily in the third week to 2 separate groups of L-thyroxin-treated animals reversed thyroxin-induced loss in body mass and rise in body temperature, blood pressure, and heart rate. Propranolol treatment increased TSH levels and decreased T3 and T4 levels in hyperthyroid animals, whereas carvedilol did not produce any effecton thyroid hormones. Carvedilol treatment reversed thyroxin induced hypertriglyceridemia, whereas propranolol treatment had no effect. Both carvedilol and propranolol prevented decrease in cholesterol levels induced by thyroxine. Compared with normal animals, L-thyroxin-treated animals showed a state of hyperglycemia, hyperinsulinaemia, impaired glucose tolerance, and insulin resistance, as inferred from elevated fasting serum glucose and insulin levels, higher area under the curve over 120 min for glucose, and decreased insulin sensitivity index (KITT). Propranolol and carvedilol treatment significantly decreased fasting serum glucose levels. Treatment with propranolol did not alter serum insulin levels, area-under-the-curve glucose, or KITT values. However, treatment with carvedilol significantly reduced area-under-the-curve glucose, decreased fasting serum insulin levels and significantly increased KITT values. In conclusion, carvedilol appears to produce favorable effects on insulin sensitivity and glycemic control and can therefore be considered as more efficacious adjunctive treatment than propranolol in hyperthyroidism.
机译：本研究旨在研究肾上腺素能拮抗剂卡维地洛和普萘洛尔对大鼠左旋甲状腺素诱发的心血管和代谢紊乱的有效性。 L-甲状腺素钠治疗（75 mg / kg体重，皮下注射，每隔一天进行3周），导致食物和水的摄入量，体温，心率，收缩压的显着增加，以及血清的增加T3，T4和甘油三酸酯水平。 L-甲状腺素治疗后，除了体重显着降低外，血清TSH和胆固醇水平也降低了。第三周每天向两组单独的经L-甲状腺素治疗的动物施用卡维地洛（10 mg / kg体重，口服）和普萘洛尔（10 mg / kg体重，腹膜内）逆转甲状腺素引起的体重减轻和上升体温，血压和心率。普萘洛尔治疗可增加甲状腺功能亢进动物的TSH水平，并降低T3和T4水平，而卡维地洛对甲状腺激素未产生任何影响。卡维地洛治疗可逆转甲状腺素诱发的高甘油三酯血症，而普萘洛尔治疗则无作用。卡维地洛和普萘洛尔均能防止甲状腺素引起的胆固醇水平降低。与正常动物相比，接受L-甲状腺素治疗的动物表现出高血糖，高胰岛素血症，葡萄糖耐量降低和胰岛素抵抗的状态，这是由于空腹血糖和胰岛素水平升高，葡萄糖在120分钟内曲线下面积增加和胰岛素敏感性指数（KITT）降低。普萘洛尔和卡维地洛治疗可显着降低空腹血清葡萄糖水平。普萘洛尔治疗不会改变血清胰岛素水平，曲线下面积葡萄糖或KITT值。但是，卡维地洛治疗可显着降低曲线下葡萄糖面积，降低空腹血清胰岛素水平并显着提高KITT值。总之，卡维地洛似乎对胰岛素敏感性和血糖控制产生有利的作用，因此在甲亢中比普萘洛尔被认为是更有效的辅助治疗。

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