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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Oxidative stress and aging: is methylglyoxal the hidden enemy?
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Oxidative stress and aging: is methylglyoxal the hidden enemy?

机译：氧化应激和衰老：甲基乙二醛是隐藏的敌人吗？

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摘要

Aging is a multifactorial process that involves changes at the cellular, tissue, organ and the whole body levels resulting in decreased functioning, development of diseases, and ultimately death. Oxidative stress is believed to be a very important factor in causing aging and age-related diseases. Oxidative stress is caused by an imbalance between oxidants such as reactive oxygen species (ROS) and antioxidants. ROS are produced from the mitochondrial electron transport chain and many oxidative reactions. Methylglyoxal (MG) is a highly reactive dicarbonyl metabolite formed during glucose, protein and fatty acid metabolism. MG levels are elevated in hyperglycemia and other conditions. An excess of MG formation can increase ROS production and cause oxidative stress. MG reacts with proteins, DNA and other biomolecules, and is a major precursor of advanced glycation end products (AGEs). AGEs are also associated with the aging process and age-related diseases such as cardiovascular complications of diabetes, neurodegenerative diseases and connective tissue disorders. AGEs also increase oxidative stress. In this review we discuss the potential role of MG in the aging process through increasing oxidative stress besides causing AGEs formation. Specific and effective scavengers and crosslink breakers of MG and AGEs are being developed and can become potential treatments to slow the aging process and prevent many diseases.
机译：衰老是一个多因素过程，涉及细胞，组织，器官和全身水平的变化，从而导致功能下降，疾病发展并最终导致死亡。氧化应激被认为是引起衰老和与年龄有关的疾病的非常重要的因素。氧化应激是由氧化剂（例如活性氧（ROS）和抗氧化剂）之间的不平衡引起的。 ROS是由线粒体电子传输链和许多氧化反应产生的。甲基乙二醛（MG）是在葡萄糖，蛋白质和脂肪酸代谢过程中形成的高反应性二羰基代谢物。在高血糖症和其他情况下，MG水平升高。过量的MG形成会增加ROS的产生并引起氧化应激。 MG与蛋白质，DNA和其他生物分子发生反应，是高级糖基化终产物（AGEs）的主要前体。 AGEs还与衰老过程和与年龄有关的疾病有关，例如糖尿病的心血管并发症，神经退行性疾病和结缔组织疾病。 AGEs也增加氧化应激。在这篇综述中，我们讨论了MG在增加衰老过程中可能通过增加氧化应激而导致AGEs形成的潜在作用。 MG和AGEs的特异性和有效的清除剂和交联剂正在开发中，可以成为减缓衰老过程和预防多种疾病的潜在疗法。

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