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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Antidepressant-like effect of simvastatin in diabetic rats
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Antidepressant-like effect of simvastatin in diabetic rats

机译：辛伐他汀对糖尿病大鼠的抗抑郁样作用

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Diabetes mellitus is accompanied by hormonal and neurochemical changes that can be associated with anxiety and depression. I investigated the antidepressant effect of simvastatin (SMV) on diabetic rats. Rats were divided into control (CTR) and streptozotocin-induced diabetic (STZ) groups and were orally administered 0, 5, or 10 mg/kg of SMV daily for 14 days, then exposed to the forced swimming test (FST). Our results showed that diabetic rats had higher immobility duration than the CTR rats, and SMV decreased this depressive-like behavior in the diabetic rats. However, clomipramine lowered the immobility time in the CTR and STZ rats. STZ decreased serotonin concentration in the hippocampus, which was reversed by SMV and clomipramine. The dopamine concentration in the hippocampus decreased in the STZ groups compared with the CTR groups. However, SMV and clomipramine had no significant effect on the dopamine levels in either the CTR or STZ groups. Corticosterone levels were increased in the untreated STZ group; SMV and clomipramine significantly decreased corticosterone levels in the STZ groups, but had no effect on the CTR groups. In conclusion, SMV exerts an antidepressant-like effect on diabetic rats that are submitted to the FST. The antidepressant-like effect of SMV in the FST appears to be mediated, at least in part, by the biochemical changes to the blood levels of corticosterone and of serotonin concentration in the hippocampus.
机译：糖尿病伴有可能与焦虑和抑郁有关的激素和神经化学变化。我研究了辛伐他汀（SMV）对糖尿病大鼠的抗抑郁作用。将大鼠分为对照组（CTR）和链脲佐菌素诱导的糖尿病（STZ）组，每天口服给予0、5或10 mg / kg SMV，持续14天，然后进行强迫游泳试验（FST）。我们的结果表明，糖尿病大鼠的固定持续时间长于CTR大鼠，而SMV可以降低糖尿病大鼠的这种抑郁样行为。但是，氯米帕明降低了CTR和STZ大鼠的固定时间。 STZ降低了海马体中5-羟色胺的浓度，这被SMV和氯米帕明逆转。与CTR组相比，STZ组海马中的多巴胺浓度降低。但是，SMV和氯米帕明对CTR或STZ组的多巴胺水平均无明显影响。未经治疗的STZ组皮质酮水平升高; SMV和氯米帕明可显着降低STZ组的皮质酮水平，但对CTR组无影响。总之，SMV对提交FST的糖尿病大鼠具有抗抑郁样作用。 SMV在FST中的抗抑郁样作用似乎至少部分是由皮质酮的血液水平和海马中血清素浓度的生化变化介导的。

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