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首页> 外文期刊>Canadian journal of anesthesia: Journal canadien d'anesthesie >Prophylactic ondansetron does not reduce the incidence of itching induced by intrathecal sufentanil: (L'administration prophylactique d'ondansetron ne reduit pas l'incidence de prurit induit par le sufentanil intrathecal).
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Prophylactic ondansetron does not reduce the incidence of itching induced by intrathecal sufentanil: (L'administration prophylactique d'ondansetron ne reduit pas l'incidence de prurit induit par le sufentanil intrathecal).

机译：预防性恩丹西酮不能降低鞘内注射舒芬太尼引起的瘙痒的发生率：（鞘内注射预防性服用丹参能预防性治疗）。

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PURPOSE: Postoperative itching after intrathecal (IT) narcotics may be a difficult and important problem for both the anesthesiologist and the patient in the postanesthetic care unit. Since some studies have reported success in preventing itching with ondansetron, we designed a prospective, randomized, double-blinded, and controlled study to test whether prophylactic iv ondansetron effectively reduces the incidence of IT sufentanil-induced pruritus. METHODS: Thirty-four patients (ASA I-III, age 18-74 yr) underwent ambulatory surgery after spinal anesthesia with IT lidocaine (15-100 mg) and IT sufentanil (10 microg). The patients were randomized into two groups to receive iv either 4 mL saline (n = 13) or 8 mg ondansetron (n = 21) before the IT injection. The incidence of pruritus and other variables was recorded. Pruritus scores were obtained with a verbal analogue score with 0 meaning none and 10 the worst itching that the patient could imagine. Statistical difference was assumed if P < 0.05. RESULTS:Ondansetron did not reduce the incidence of pruritus (77 vs 81%) compared to placebo (P = 1.000). The pruritus scores (4.4 vs 3.6) of the two groups were not significantly different (P = 0.670). CONCLUSIONS: There are contradictory findings in the literature regarding the effectiveness of ondansetron in preventing narcotic-induced itching. Although some studies have indicated that ondansetron could prevent this side effect of IT narcotics, a recent report suggested that ondansetron is not effective in preventing narcotic-induced itching (sufentanil-morphine) after a Cesarean section. In the present study we obtained similar, negative results.
机译：目的：鞘内麻醉（IT）后麻醉后瘙痒对于麻醉师和麻醉后护理部门的患者而言可能是一个困难而重要的问题。由于一些研究报告成功预防了恩丹西酮的瘙痒，因此我们设计了一项前瞻性，随机，双盲和对照研究，以测试预防性静脉注射恩丹西酮是否能有效降低IT舒芬太尼诱发的瘙痒症的发生率。方法：34例患者（ASA I-III，年龄18-74岁）在脊髓麻醉后接受IT利多卡因（15-100 mg）和IT舒芬太尼（10 microg）的非卧床手术。将患者随机分为两组，在IT注射前静脉注射4 mL生理盐水（n = 13）或8 mg恩丹西酮（n = 21）。记录瘙痒和其他变量的发生率。瘙痒评分是通过口头类似评分获得的，0表示无，10表示患者可以想象的最严重的瘙痒。如果P <0.05，则认为存在统计学差异。结果：与安慰剂相比，恩丹西酮未减少瘙痒的发生率（77比81％）（P = 1.000）。两组的瘙痒评分（4.4 vs 3.6）无显着差异（P = 0.670）。结论：关于恩丹西酮在预防麻醉药引起的瘙痒方面的有效性，文献中存在矛盾的发现。尽管一些研究表明，恩丹西酮可以预防IT麻醉品的这种副作用，但最近的一份报告表明，恩丹西酮在剖宫产术后不能有效预防麻醉药引起的瘙痒（舒芬太尼吗啡）。在本研究中，我们获得了相似的阴性结果。

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