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3-hydroxypyridinone derivatives as metal-sequestering agents for therapeutic use

机译：3-羟基吡啶酮衍生物作为治疗性金属螯合剂

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摘要

Although iron is one of the most important metal ions for living organisms, it becomes toxic when in excess or misplaced. This review presents a glance at representative examples of hydroxypyridinone-based chelators, which have been recently developed as potential clinically useful drugs for metal overload diseases, mostly associated with excess of iron but also other hard metal-ions. It also includes a detailed discussion on the factors assisting chelator design strategy toward fulfillment of the most relevant biochemical properties of hydroxypyridinone chelators, highlighting structure-activity relationships and a variety of potential clinical applications, beyond chelatotherapy. This study appears as a response to the growing interest on metal chelation therapy and opens new perspectives of possible applications in future medicine.
机译：尽管铁是生物体最重要的金属离子之一，但过量或放错位置会产生毒性。这篇综述介绍了基于羟基吡啶酮的螯合剂的代表性实例，这些螯合剂最近已被开发为潜在的临床上有用的药物，可用于金属超负荷疾病，大多数与铁过多，但也与其他硬金属离子有关。它还包括有关有助于螯合剂设计策略实现羟基吡啶酮螯合剂最相关生化特性的因素的详细讨论，重点介绍了结构与活性的关系以及螯合疗法以外的各种潜在临床应用。这项研究是对金属螯合疗法日益增长的兴趣的回应，并为未来医学中可能的应用开辟了新的前景。

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