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首页> 外文期刊>Future medicinal chemistry >Inosine 5 '-monophosphate dehydrogenase inhibitors as antimicrobial agents: recent progress and future perspectives
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Inosine 5 '-monophosphate dehydrogenase inhibitors as antimicrobial agents: recent progress and future perspectives

机译：肌苷5'-单磷酸脱氢酶抑制剂作为抗菌剂的最新进展和展望

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摘要

Inosine 5-monophosphate dehydrogenase (IMPDH), a crucial enzyme required for de novo synthesis of guanine nucleotides, is an important target for cancer, bacterial, parasitic and viral infections and autoimmune disorders. Several classes of IMPDH inhibitors are known in the literature. The current review succinctly summarizes the progress made in the design and development of IMPDH inhibitors as antimicrobial agents in last five years or so. The focus is on the inhibitor and enzyme structural features responsible for imparting selectivity for the microbial over the host enzyme. Future perspectives clearly outline the inhibitor design opportunities available in this area to address the present challenges of drug resistance and re-emergence of newer and deadly strains of microbes, posing a serious threat to public.
机译：肌苷5-一磷酸脱氢酶（IMPDH）是鸟嘌呤核苷酸从头合成所需的关键酶，是癌症，细菌，寄生虫和病毒感染以及自身免疫性疾病的重要靶标。在文献中已知几类IMPDH抑制剂。本综述简要总结了近五年来在IMPDH抑制剂作为抗菌剂的设计和开发方面取得的进展。重点是抑制剂和酶的结构特征，这些特征负责赋予微生物对宿主酶的选择性。未来的观点清楚地概述了该领域可利用的抑制剂设计机会，以应对当前的耐药性挑战以及新型和致命微生物菌株的再出现，这对公众构成了严重威胁。

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