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首页> 外文期刊>Macromolecular symposia >Polymer-based biomaterials as dressings for chronic stagnating wounds
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Polymer-based biomaterials as dressings for chronic stagnating wounds

机译：聚合物基生物材料作为慢性停滞伤口的敷料

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Chronic wounds, such as venous, pressure, and diabetic ulcers, are difficult to heal and represent a rising social and economical problem. Compared to acute wounds, non-healing wounds contain elevated levels of neutrophil elastase, pro-inflammatory cytokines (IL-1β, IL-6, IL-8), and matrix metalloproteases (MMP-2, MMP-9, MMP-1β) as well as free radicals. Their overproduction perpetuates the inflammatory phase resulting in severe tissue damage and degradation of growth factors. Consequently, wound closure is prevented and the wound remains non-healing for month or even years. The increasing numbers of patients suffering from wounds that fail to heal are a significant challenge for health care professionals. Wound dressings play an important role in the entire management of these wounds. New materials and treatment strategies are needed to improve wound care. Recent advances in the field of biomaterials and their medical applications indicate the significance and potential of various natural polymers in the development of novel classes of wound dressings. Native polymers are an ideal source for bio-active wound dressings because of their availability and biocompatibility. Hence, several studies have been conducted to explore the influence of wound dressings consisting of collagen, oxidized regenerated cellulose, bacterial cellulose, chitosan, or alginate on the destructive milieu in chronic wounds.
机译：诸如静脉，压力和糖尿病性溃疡之类的慢性伤口难以治愈，并且代表着日益严重的社会和经济问题。与急性伤口相比，非愈合伤口的中性粒细胞弹性蛋白酶，促炎性细胞因子（IL-1β，IL-6，IL-8）和基质金属蛋白酶（MMP-2，MMP-9，MMP-1β）水平升高以及自由基。它们的过量生产使炎症期永久化，导致严重的组织损伤和生长因子的降解。因此，可以防止伤口闭合，并且伤口可以在一个月甚至几年内保持不愈合。越来越多的患者无法治愈伤口，这对医疗保健专业人员构成了重大挑战。伤口敷料在这些伤口的整个处理中起着重要作用。需要新的材料和治疗策略来改善伤口护理。生物材料及其医学应用领域的最新进展表明，各种天然聚合物在新型伤口敷料开发中的重要性和潜力。天然聚合物由于具有可用性和生物相容性，因此是生物活性伤口敷料的理想来源。因此，已经进行了一些研究来探索由胶原，氧化的再生纤维素，细菌纤维素，壳聚糖或藻酸盐组成的伤口敷料对慢性伤口的破坏性环境的影响。

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