...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Magnetic resonance in medicine: official journal of the Society of Magnetic Resonance in Medicine >Manganese-enhanced magnetic resonance imaging of mouse brain after systemic administration of MnCl2: dose-dependent and temporal evolution of T1 contrast.
【24h】

Manganese-enhanced magnetic resonance imaging of mouse brain after systemic administration of MnCl2: dose-dependent and temporal evolution of T1 contrast.

机译：全身施用MnCl2后，小鼠大脑的锰增强磁共振成像：T1剂量依赖性和时间演变对比。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Manganese is a useful contrast agent for MRI of animals. Previously, it has been shown that systemic doses of MnCl(2) provide unique contrast in the rodent brain, enabling visualization of neuroarchitecture. The present work investigates the dose and temporal dependence of brain enhancement after i.v. administration of MnCl(2). Varying doses of MnCl(2) (9-175 mg/kg) were administered to mice from 0 to 24 h prior to T(1)-weighted manganese-enhanced MRI (MEMRI) at 11.7 T. Pre-MnCl(2) T(1) values measured in different brain regions ranged from 1.17 +/- 0.03 to 1.76 +/- 0.01 s. Post-MnCl(2) T(1) measured 24 hr after administration of MnCl(2) were significantly decreased, even after the lowest dose of MnCl(2). The largest decreases occurred in the pituitary gland, where post-MnCl(2) T(1) ranged from 231 +/- 23 ms following the lowest dose to 143 +/- 43 ms after the highest dose, while the smallest decreases were observed in cortex (post-MnCl(2) T(1) = 1060 +/- 5 ms for low dose and 637 +/- 5 ms for high dose). The contrast resulting after 14 hr did not change up to 24 hr. Enhancement first occurred in subarachnoid spaces, followed by ventricles and periventricular tissues, and finally reached the remainder of the brain. Cortical layers were detected at higher doses (>88 mg/kg) and olfactory bulb layers were detected with the lowest dose (9 mg/kg). Temporal evolution of the enhancement of the olfactory bulb layers was observed. In some regions of the brain, such as hippocampus and thalamus, the changes in contrast detected between 2 and 14 hr used very specific pathways. These results demonstrate that both the dose and the time after MnCl(2) can be manipulated to optimize brain contrast in a region-specific manner.
机译：锰是用于动物MRI的有用造影剂。以前，已经显示全身剂量的MnCl（2）在啮齿动物的大脑中提供独特的对比，从而使神经体系结构可视化。本研究调查了静脉输注后大脑增强的剂量和时间依赖性。 MnCl（2）的给药。在11.7 T的T（1）加权锰增强MRI（MEMRI）之前的0到24小时内，向小鼠施用不同剂量的MnCl（2）（9-175 mg / kg）。Pre-MnCl（2）T （1）在不同大脑区域测得的值范围为1.17 +/- 0.03至1.76 +/- 0.01 s。施用MnCl（2）后24小时测得的后MnCl（2）T（1）显着降低，即使在最低剂量的MnCl（2）之后也是如此。最大的下降发生在垂体腺，其中MnCl（2）T（1）在最低剂量后的231 +/- 23 ms到最高剂量后的143 +/- 43 ms范围内，而观察到的下降最小在皮层中（低剂量后MnCl（2）T（1）= 1060 +/- 5毫秒，高剂量时637 +/- 5毫秒）。 14小时后产生的对比度直到24小时都没有变化。增强首先发生在蛛网膜下腔，然后是心室和脑室周围组织，最后到达大脑的其余部分。以较高的剂量（> 88 mg / kg）检测到皮质层，以最低的剂量（9 mg / kg）检测到嗅球层。观察到嗅球层增强的时间演变。在大脑的某些区域，例如海马和丘脑，在2到14小时之间检测到的对比度变化使用了非常特殊的途径。这些结果表明，可以控制剂量和MnCl（2）之后的时间以区域特定的方式优化大脑对比度。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号