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首页> 外文期刊>Behavioural Brain Research: An International Journal >Manganese-enhanced magnetic resonance imaging (MEMRI) of rat brain after systemic administration of MnCl?: hippocampal signal enhancement without disruption of hippocampus-dependent behavior.
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Manganese-enhanced magnetic resonance imaging (MEMRI) of rat brain after systemic administration of MnCl?: hippocampal signal enhancement without disruption of hippocampus-dependent behavior.

机译：全身给予MnCl2后，大鼠脑的锰增强磁共振成像（MEMRI）：海马信号增强而不会破坏海马依赖性行为。

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摘要

Manganese (Mn(2+))-enhanced magnetic resonance (MR) imaging (MEMRI) in rodents offers unique opportunities for the longitudinal study of hippocampal structure and function in parallel with cognitive testing. However, Mn(2+) is a potent toxin and there is evidence that it can interfere with neuronal function. Thus, apart from causing adverse peripheral side effects, Mn(2+) may disrupt the function of brain areas where it accumulates to produce signal enhancement and, thereby, Mn(2+) administration may confound cognitive testing. Here, we examined in male adult Lister hooded rats if a moderate systemic dose of MnCl? (200 μmol/kg; two intraperitoneal injections of 100 μmol/kg separated by 1 h) that produces hippocampal MR signal enhancement would disrupt hippocampal function. To this end, we used a delayed-matching-to-place (DMP) watermaze task, which requires rapid allocentric place learning and is highly sensitive to interference with hippocampal function. Tested on the DMP task 1 h and 24 h after MnCl? injection, rats did not show any impairment in indices of memory performance (latencies, search preference) or any sensorimotor effects. However, MnCl? injection caused acute peripheral effects (severe ataxia and erythema, i.e. redness of paws, ears, and nose) which subsided over 30 min. Additionally, rats injected with MnCl? showed reduced weight 1 day after injection and failed to reach the normal weight-growth curve of control rats within the 16 days monitored. Our results indicate that 200 μmol/kg MnCl? produces hippocampal MR signal enhancement without disrupting hippocampus-dependent behavior on a rapid place learning task, even though attention must be paid to peripheral side effects.
机译：啮齿动物中的锰（Mn（2+））增强磁共振（MR）成像（MEMRI）为纵向研究海马结构和功能以及认知测试提供了独特的机会。但是，Mn（2+）是一种有效的毒素，有证据表明它可以干扰神经元功能。因此，除了引起不利的外周副作用外，Mn（2+）可能会破坏其积累以产生信号增强作用的大脑区域的功能，因此，Mn（2+）的给药可能会混淆认知测试。在这里，我们检查了成年成年李斯特（Lister）雄性成年雄性大鼠是否有中等全身剂量的MnCl2？ （200μmol/ kg;两次腹膜内注射100μmol/ kg，间隔1 h），会增强海马MR信号，从而破坏海马功能。为此，我们使用了延迟到位匹配（DMP）的水迷宫任务，该任务需要快速的异位中心学习并且对干扰海马功能高度敏感。在MnCl2处理后1小时和24小时对DMP任务进行测试。注射后，大鼠的记忆力指标（潜伏期，搜索偏好）没有任何损害或任何感觉运动效应。但是，MnCl？注射引起的急性周围效应（严重的共济失调和红斑，即爪子，耳朵和鼻子发红）在30分钟内消失。另外，大鼠注射了MnCl2？在注射后1天显示体重减轻，并且在监测的16天内未达到对照组大鼠的正常体重增长曲线。我们的结果表明200μmol/ kg MnCl2？即使必须注意周围的副作用，也能在不影响快速学习场所学习任务的海马依赖行为的情况下产生海马MR信号增强。

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