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首页> 外文期刊>Frontiers in bioscience: a journal and virtual library >Cell cycle control as a basis for cancer chemoprevention through dietary agents.
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Cell cycle control as a basis for cancer chemoprevention through dietary agents.

机译：细胞周期控制作为通过饮食药物化学预防癌症的基础。

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The development of cancer is associated with disorders in the regulation of the cell cycle. The purpose of this review is to briefly summarize the known sequence of events that regulate cell cycle progression with an emphasis on the checkpoints and the mechanisms cell employ to insure DNA stability in the face of genotoxic stress. Key transitions in the cell cycle are regulated by the activities of various protein kinase complexes composed of cyclin and cyclin-dependent kinases (CDK) molecules. The cyclins are CDK binding partners which are required for kinase activity and their protein levels are intimately linked to the cell cycle stage. CDK activity can be regulated by other mechanisms, such as phosphorylation events, that may contribute to deregulation of cell cycle and the development of cancer. While fruits and vegetables are recommended for prevention of cancer, their active ingredients and mechanisms of action are less well understood. Here, we briefly present evidence that dietary agents identified from fruits and vegetables can act to modulate the effects of deregulated cell cycle checkpoints, and that this may contribute to the prevention of cancer. The agents include apigenin (celery, parsley), curcumin (turmeric), (-)-epigallocatechin-3-gallate (green tea), resveratrol (red grape, peanuts and berries), genistein (soybean), and silymarin (milk thistle). The teachings of Hippocrates are still true "let food be thy medicine and medicine be thy food".
机译：癌症的发展与细胞周期调节的异常有关。这篇综述的目的是简要概述调节细胞周期进程的已知事件序列，重点是检查点和细胞在面对遗传毒性胁迫时可确保DNA稳定性的机制。细胞周期中的关键转变受细胞周期蛋白和细胞周期蛋白依赖性激酶（CDK）分子组成的各种蛋白激酶复合物的活性调节。细胞周期蛋白是激酶活性所必需的CDK结合伴侣，它们的蛋白质水平与细胞周期阶段密切相关。 CDK活性可以通过其他机制来调节，例如磷酸化事件，这可能有助于细胞周期的失调和癌症的发展。虽然推荐使用水果和蔬菜来预防癌症，但对它们的有效成分和作用机理的了解却很少。在这里，我们简要介绍证据表明，从水果和蔬菜中识别出的饮食成分可以起到调节细胞周期检查点失控的作用，并且这可能有助于预防癌症。药剂包括芹菜素（芹菜，欧芹），姜黄素（姜黄），（-）-epigallocatechin-3-gallate（绿茶），白藜芦醇（红葡萄，花生和浆果），染料木黄酮（大豆）和水飞蓟素（水飞蓟）。 。希波克拉底的教义仍然是正确的：“让食物成为你的药，让药物成为你的食物”。

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