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首页> 外文期刊>Cancer epidemiology >Functional polymorphisms to modulate luminal lipid exposure and risk of colorectal cancer
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Functional polymorphisms to modulate luminal lipid exposure and risk of colorectal cancer

机译：功能性多态性调节管腔脂质暴露和结直肠癌的风险

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Purpose Fat absorption may play a crucial role in colorectal carcinogenesis by determining intra-colonic exposure to potentially carcinogenic lipid metabolites. Methods We conducted a population-based case-control study that included 1163 cases and 1501 controls to examine whether individuals who carry genetic variants associated with lower lipid absorption have a higher risk of colorectal cancer. Using Taqman assay, we determined FABP2 alanine (A)/threonine (T) polymorphism at codon 54 in exon-2 and APOE isoforms. Multivariable odds ratios (OR) and 95% confidence intervals (CI) were calculated by unconditional logistic regression models, assuming FABP2 A54 and APO non-E4 as high risk alleles. Results We found no associations with either of the polymorphisms. The OR associated with FABP2 A54 homozygotes compared with the others was 1.01 (95% CI; 0.86-1.45) and that for non-ApoE4 carriers compared with carries was 0.95 (95% CI; 0.80-1.13). However, there was a statistically significant negative interaction between total fat intake and FABP2 AA genotypes (p = 0.025), indicating that the risk of colorectal cancer associated with this polymorphism is higher in the subjects with lower fat intake. Conclusions These results suggest that these SNPs may not be useful in predicting colorectal cancer risk in populations with high fat intake.
机译：目的通过确定结肠内对潜在致癌脂质代谢物的暴露，脂肪吸收可能在结直肠癌发生中起关键作用。方法我们进行了一项基于人群的病例对照研究，包括1163例病例和1501例对照者，以检查携带与较低脂质吸收相关的遗传变异的个体是否具有较高的结直肠癌风险。使用Taqman分析，我们确定外显子2和APOE同工型在第54位密码子处的FABP2丙氨酸（A）/苏氨酸（T）多态性。假设FABP2 A54和APO non-E4为高风险等位基因，通过无条件逻辑回归模型计算多变量比值比（OR）和95％置信区间（CI）。结果我们发现与任何一个多态性都没有关联。与FABP2 A54纯合子相关的OR与其他OR相比为1.01（95％CI; 0.86-1.45），与非ApoE4载体相比与携带的OR为0.95（95％CI; 0.80-1.13）。但是，在总脂肪摄入和FABP2 AA基因型之间存在统计学上显着的负相关性（p = 0.025），表明在脂肪摄入较低的受试者中，与该多态性相关的结直肠癌的风险较高。结论这些结果表明，这些SNP可能无法用于预测高脂肪摄入人群的结直肠癌风险。

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