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Thymic involution in ontogenesis: Role in aging program

机译:胸腺退化涉及本体发育:在衰老程序中的作用

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摘要

In most mammals, involution of the thymus occurs with aging. In this issue of Biochemistry (Moscow) devoted to phenoptosis, A. V. Khalyavkin considered involution of a thymus as an example of the program of development and further-of proliferation control and prevention of tumor growth. However, in animals devoid of a thymus (e.g. naked mice), stimulation of carcinogenesis, but not its prevention was observed. In this report, we focus on the involution of the thymus as a manifestation of the aging program (slow phenoptosis). We also consider methods of reversal/arrest of this program at different levels of organization of life (cell, tissue, and organism) including surgical manipulations, hormonal effects, genetic techniques, as well as the use of conventional and mitochondria-targeted antioxidants. We conclude that programmed aging (at least on the model of age-dependent thymic atrophy) can be inhibited.
机译:在大多数哺乳动物中,胸腺的退化随着年龄的增长而发生。在本期专门研究表皮凋亡的生物化学杂志(莫斯科)中,A。V. Khalyavkin将胸腺的退化视为开发和进一步控制增殖以及预防肿瘤生长的一个例子。但是,在没有胸腺的动物(例如裸鼠)中,刺激了致癌作用,但未观察到其预防作用。在本报告中,我们着重于胸腺的退化,作为衰老程序的一种表现(慢表皮凋亡)。我们还考虑了在生命的不同组织(细胞,组织和生物)的不同级别逆转/逮捕该方法的方法,包括手术操作,荷尔蒙作用,遗传技术以及常规和针对线粒体的抗氧化剂的使用。我们得出结论,可以抑制程序性衰老(至少在与年龄有关的胸腺萎缩模型上)。

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