...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biochemistry >Temporal scaling of age-dependent mortality: Dynamics of aging in Caenorhabditis elegans is easy to speed up or slow down, but its overall trajectory is stable
【24h】

Temporal scaling of age-dependent mortality: Dynamics of aging in Caenorhabditis elegans is easy to speed up or slow down, but its overall trajectory is stable

机译：随年龄变化的死亡率的时间尺度：秀丽隐杆线虫的衰老动力学易于加速或减慢，但其总体轨迹是稳定的

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The dynamics of aging is often described by survival curves that show the proportion of individuals surviving to a given age. The shape of the survival curve reflects the dependence of mortality on age, and it varies greatly for different organisms. In a recently published paper, Stroustrup and coauthors ((2016) Nature, {vn530}, 103-107) showed that many factors affecting the lifespan of Caenorhabditis elegans do not change the shape of the survival curve, but only stretch or compress it in time. Apparently, this means that aging is a programmed process whose trajectory is difficult to change, although it is possible to speed it up or slow it down. More research is needed to clarify whether the "rule of temporal scaling" is applicable to other organisms. A good indicator of temporal scaling is the coefficient of lifespan variation: similar values of this coefficient for two samples indicate similar shape of the survival curves. Preliminary results of experiments on adaptation of Drosophila melanogaster to unfavorable food show that temporal scalability of survival curves is sometimes present in more complex organisms, although this is not a universal rule. Both evolutionary and environmental changes sometimes affect only the average lifespan without changing the coefficient of variation (in this case, temporal scaling is present), but often both parameters (i.e. both scale and shape of the survival curve) change simultaneously. In addition to the relative stability of the coefficient of variation, another possible argument in favor of genetic determination of the aging process is relatively low variability of the time of death, which is sometimes of the same order of magnitude as the variability of timing of other ontogenetic events, such as the onset of sexual maturation.
机译：衰老的动态通常由生存曲线来描述，该曲线显示了生存到给定年龄的个体所占的比例。生存曲线的形状反映了死亡率对年龄的依赖性，并且对于不同的生物它变化很大。在最近发表的论文中，Stroustrup和合著者（（2016）Nature，{vn530}，103-107）表明，影响秀丽隐杆线虫寿命的许多因素不会改变生存曲线的形状，而只会拉伸或压缩生存曲线。时间。显然，这意味着老化是一个程序化的过程，其轨迹很难改变，尽管可以加速或减速。需要更多的研究来阐明“时间尺度定律”是否适用于其他生物。时间尺度的一个很好的指标是寿命变化系数：两个样品的该系数的相似值表示生存曲线的形状相似。果蝇适应不良食物的实验的初步结果表明，生存曲线的时间可扩展性有时出现在更复杂的生物中，尽管这不是普遍的规则。进化和环境变化有时只影响平均寿命，而不会改变变异系数（在这种情况下，存在时间标度），但常常两个参数（即生存曲线的标度和形状）同时变化。除了变异系数的相对稳定性外，另一个有利于遗传确定衰老过程的可能论据是死亡时间的变异性相对较低，有时与其他人的时间变异性相同。个体发育事件，例如性成熟的开始。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号