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首页> 外文期刊>Mayo Clinic Proceedings >Effect of differing immunization policies on circulating measles antibody levels in US and Canadian children.
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Effect of differing immunization policies on circulating measles antibody levels in US and Canadian children.

机译：不同的免疫策略对美国和加拿大儿童中循环麻疹抗体水平的影响。

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OBJECTIVE: To examine the effect of differing age-at-immunization policies on measles antibody levels in US children immunized at the age of 15 months compared with Canadian children immunized at the age of 12 months. SUBJECTS AND METHODS: Healthy, volunteer US and Canadian children aged 6 to 11 years who had been immunized with a single dose of the measles vaccine were enrolled from 1991 to 1993. Measles antibody was measured with a whole-virus, measles-specific IgG enzyme-linked immunoassay. Age, race, sex, country of residence, general health status, age at time of measles immunization, and time from immunization to sampling were recorded. RESULTS: Of the 1052 children enrolled in the study, US children (n=719) had a significantly higher measles seroprevalence (87%) compared with Canadian children (n=333) (76%; P<.001). After adjustment for time from immunization and age at immunization, the differences in seropositive rates were no longer significant (odds ratio [OR], 1.53; 95% confidence interval, 0.87-2.69; P=.15). We found a significant dose-response relationship between age at the time of immunization and the odds of being seropositive after immunization, with ORs varying from 1 with immunization at 13 months or younger to 2.30 with immunization at 16 months of age (P=.01). CONCLUSIONS: The current US policy of immunizing with the first dose of measles at the age of 12 months may be less effective than a policy of immunizing at 12 to 15 months of age. These findings may be highly significant as we move toward an era in which measles exposure may be rare and policies are developed to eradicate measles.
机译：目的：研究15岁以下免疫的美国儿童与12个月龄免疫的加拿大儿童相比，不同的免疫接种年龄策略对麻疹抗体水平的影响。研究对象和方法：1991年至1993年纳入了健康，自愿的美国和加拿大6至11岁儿童，他们均接受过单次麻疹疫苗的免疫接种。麻疹抗体是通过全病毒，麻疹特异性IgG酶来测量的联免疫分析。记录年龄，种族，性别，居住国家，总体健康状况，麻疹免疫时的年龄以及从免疫到取样的时间。结果：在这项研究的1052名儿童中，美国儿童（n = 719）的麻疹血清阳性率（87％）比加拿大儿童（n = 333）（76％; P <.001）高得多。在调整了免疫接种的时间和免疫接种的年龄后，血清阳性率的差异不再显着（优势比[OR]为1.53; 95％置信区间为0.87-2.69; P = .15）。我们发现免疫时的年龄与免疫后血清阳性的几率之间存在显着的剂量反应关系，OR值从13个月或以下的免疫接种的1到16个月大的免疫接种的2.30有所不同（P = .01） ）。结论：美国现行的在12个月大时首次接种麻疹疫苗的政策可能不如在12到15个月大时进行免疫的政策有效。随着我们迈向一个罕见的麻疹暴露时代，并制定了根除麻疹的政策，这些发现可能非常重要。

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