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首页> 外文期刊>Medicine and science in sports and exercise >Estrogen replacement, muscle composition, and physical function: The Health ABC Study.
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Estrogen replacement, muscle composition, and physical function: The Health ABC Study.

机译：雌激素替代，肌肉组成和身体功能：Health ABC研究。

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PURPOSE: Although the beneficial effects of estrogen use on cardiovascular and cognitive function in postmenopausal women have been recently discredited, controversy remains regarding its usefulness for maintaining skeletal muscle mass or strength. Therefore, the purpose of this study was to determine whether estrogen use is associated with enhanced muscle composition and, if so, whether this translates into improved strength and physical function. METHODS: Cross-sectional analysis of 840 well-functioning community-dwelling white women (current estrogen replacement therapy (ERT) users = 259, nonusers = 581) aged 70-79 yr participating in the Health, Aging and Body Composition Study. Muscle composition of the midthigh by computed tomography included cross-sectional area (CSA) of the quadriceps, hamstrings, intermuscular fat and subcutaneous fat, and muscle attenuation in Hounsfield units (HU) as a measure of muscle density. Isometric hand grip and isokinetic knee extensor strength were assessed by dynamometry. Physical function was assessed using a summary scale that included usual 6-m walk and narrow walk speed, repeated chair stands, and standing balance. RESULTS: In analyses of covariance adjusted for relevant confounders, quadriceps muscle CSA and HU were greater in current ERT than non-ERT women (P < 0.05). Grip strength was also greater (P < 0.05) in women taking ERT while knee extensor strength approached significance (P < 0.10). However, differences in muscle composition and strength were modest at < or =3.3%. There was no difference by ERT status for the hamstring muscles, fat CSA, or for physical function. CONCLUSION: The associations between ERT and muscle composition and strength were minor and did not translate into improved physical function. Initiation of ERT for preservation of muscle composition and function may not be indicated.
机译：目的：尽管最近雌激素的使用对绝经后妇女的心血管和认知功能的有益作用已被人们公认，但关于其在维持骨骼肌质量或强度方面的作用仍存在争议。因此，本研究的目的是确定雌激素的使用是否与增强的肌肉成分有关，如果是，则可以将其转化为强度和身体功能的改善。方法：对参加健康，老龄化和身体成分研究的年龄在70-79岁的840名功能良好的社区居民白人妇女（当前使用雌激素替代疗法（ERT）的使用者= 259，非使用者= 581）进行横断面分析。通过计算机断层摄影术得出的中大腿肌肉成分包括股四头肌，绳肌，肌间脂肪和皮下脂肪的横截面积（CSA），以及以Hounsfield单位（HU）表示的肌肉衰减，作为肌肉密度的度量。通过测力法评估等距手的抓地力和等速膝关节伸肌的力量。身体机能的评估采用了通常的6米步行和狭窄的步行速度，重复的椅子站立和站立平衡的总表。结果：在对相关混杂因素进行校正的协方差分析中，目前的ERT股四头肌CSA和HU大于非ERT妇女（P <0.05）。接受ERT的女性的握力也更大（P <0.05），而膝盖伸肌的力量则接近（P <0.10）。但是，肌肉组成和强度的差异适度在<或= 3.3％。绳肌，脂肪CSA或身体功能的ERT状态无差异。结论：ERT与肌肉组成和力量之间的关联很小，并且没有转化为改善的身体功能。可能不会指示为保护肌肉成分和功能而启动ERT。

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