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首页> 外文期刊>Medical Physics >In vivo cancer diagnosis with optical spectroscopy and acoustically induced blood stasis using a murine MCa35 model.
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In vivo cancer diagnosis with optical spectroscopy and acoustically induced blood stasis using a murine MCa35 model.

机译：使用小鼠MCa35模型通过光谱学和声学诱发的血淤进行体内癌症诊断。

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Ultrasound-induced blood stasis has been observed for more than 30 years. Most of the literature has been focused on the health risks associated with this phenomenon and methods employed to prevent stasis from occurring during ultrasound imaging. To date, experimental observations have been either in vitro or invasive. The current work demonstrates ultrasound-induced blood stasis in murine normal leg muscle versus tumor-bearing legs, observed through noninvasive measurements of optical spectroscopy, and discusses possible diagnostic uses for this previously undesirable effect of ultrasound. We demonstrate that, using optical spectroscopy, effects of ultrasound can be used to differentiate tumor from normal leg muscle tissue in mice. Finally, we propose a novel diagnostic algorithm that quantitatively differentiates tumor from nontumor with maximum specificity 0.83, maximum sensitivity 0.79, and area under receiver-operating-characteristics curve 0.90.
机译：超声引起的血瘀现象已观察超过30年。大多数文献都集中在与这种现象相关的健康风险以及在超声成像过程中用于防止淤滞发生的方法。迄今为止，实验观察是体外的或侵入性的。当前的工作证明了通过光学光谱的非侵入性测量观察到的小鼠正常腿部肌肉与荷瘤腿部中的超声诱发的血瘀，并讨论了超声这种先前不良作用的可能的诊断用途。我们证明，使用光谱学，超声的影响可用于区分小鼠正常腿部肌肉组织中的肿瘤。最后，我们提出了一种新颖的诊断算法，该算法可定量区分肿瘤与非肿瘤，最大特异性为0.83，最大灵敏度为0.79，接收者操作特征曲线下的面积为0.90。

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