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首页> 外文期刊>Medical Physics >Statistical analysis of dose-volume and dose-wall histograms for rectal toxicity following 3D-CRT in prostate cancer.
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Statistical analysis of dose-volume and dose-wall histograms for rectal toxicity following 3D-CRT in prostate cancer.

机译：前列腺癌3D-CRT后直肠毒性的剂量-体积和剂量-壁直方图的统计分析。

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摘要

The purpose of this paper is to determine the correlation between dose-volume histogram (DVH) and dose wall-histogram (DWH) in the evaluation of rectal complications for prostate cancer patients treated with three-dimensional conformal radiotherapy (3D-CRT). A retrospective analysis of DVHs and DWHs of a subset of 25 prostate cancer patients treated with 3D-CRT was performed. For every patient the rectum and the rectal wall (inner and outer surface) were contoured. Median ICRU radiation dose of 79.4 Gy was administered. Correlation between DVHs and DWHs parameters was investigated by the nonparametric Spearman test and by linear regression analysis. The results showed a statistically significant linear correlation between pairs of DVH and DWH dosimetric parameters with Spearman correlation values (S) bigger than 0.8, with p values better than 0.0005 (two-sided) when the emptied rectum is considered. The variation of S and linear fit slope values [b(1)] showed a very similar functional shape with a minimum at 91% ICRU dose [S =0.83, b(1)=0.65]. The present study confirms a high correlation (>80%) between DVH and DWH of the rectum following 3D-CRT for prostate cancer. The derived advantage is that the contouring of inner surface of rectum could be obviated in almost 90% of patients when performing predictive models for rectal complications based on dosimetric variables under the standard treatment conditions specified in this study.
机译：本文的目的是在评估三维保形放射疗法（3D-CRT）治疗的前列腺癌患者的直肠并发症时，确定剂量-体积直方图（DVH）与剂量壁直方图（DWH）之间的相关性。对25例接受3D-CRT治疗的前列腺癌患者的DVH和DWH进行回顾性分析。对于每位患者，直肠和直肠壁（内表面和外表面）均具有轮廓。给予79.4 Gy的中位ICRU辐射剂量。通过非参数Spearman检验和线性回归分析研究了DVH和DWH参数之间的相关性。结果显示，在考虑排空直肠时，Spearman相关值（S）大于0.8的DVH和DWH剂量参数对之间具有统计学上显着的线性相关性，p值大于0.0005（双面）。 S和线性拟合斜率值[b（1）]的变化显示出非常相似的功能形状，ICRU剂量为91％时最小值最小[S = 0.83，b（1）= 0.65]。本研究证实了前列腺癌3D-CRT后直肠的DVH与DWH之间的高度相关性（> 80％）。在本研究中指定的标准治疗条件下，根据剂量变量执行直肠并发症的预测模型时，几乎90％的患者可避免直肠内表面的轮廓变大。

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