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首页> 外文期刊>British journal of anaesthesia >Prediction of arterial oxygen partial pressure after changes in FIO: validation and clinical application of a novel formula.
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Prediction of arterial oxygen partial pressure after changes in FIO: validation and clinical application of a novel formula.

机译：FIO变化后的动脉血氧分压的预测：一种新配方的验证和临床应用。

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BACKGROUND: Existing methods allow prediction of Pa(O) during adjustment of Fi(O). However, these are cumbersome and lack sufficient accuracy for use in the clinical setting. The present studies aim to extend the validity of a novel formula designed to predict Pa(O) during adjustment of Fi(O) and to compare it with the current methods. METHODS: Sixty-seven new data sets were collected from 46 randomly selected, mechanically ventilated patients. Each data set consisted of two subsets (before and 20 min after Fi(O) adjustment) and contained ventilator settings, pH, and arterial blood gas values. We compared the accuracy of Pa(O) prediction using a new formula (which utilizes only the pre-adjustment Pa(O) and pre- and post-adjustment Fi(O) with prediction using assumptions of constant Pa(O)/Fi(O) or constant Pa(O)/Pa(O). Subsequently, 20 clinicians predicted Pa(O) using the new formula and using Nunn's isoshunt diagram. The accuracy of the clinician's predictions was examined. RESULTS: The 95% limits of agreement (LA(95%)) between predicted and measured Pa(O) in the patient group were: new formula 0.11 (2.0) kPa, Pa(O)/Fi(O) -1.9 (4.4) kPa, and Pa(O)/Pa(O) -1.0 (3.6) kPa. The LA(95%) of clinicians' predictions of Pa(O) were 0.56 (3.6) kPa (new formula) and -2.7 (6.4) kPa (isoshunt diagram). CONCLUSIONS: The new formula's prediction of changes in Pa(O) is acceptably accurate and reliable and better than any other existing method. Its use by clinicians appears to improve accuracy over the most popular existing method. The simplicity of the new method may allow its regular use in the critical care setting.
机译：背景：现有方法允许在调整Fi（O）期间预测Pa（O）。然而，这些麻烦且在临床环境中使用时缺乏足够的准确性。本研究旨在扩展设计用于预测Fi（O）调节过程中Pa（O）的新颖公式的有效性，并将其与当前方法进行比较。方法：从46名随机选择的机械通气患者中收集了67个新数据集。每个数据集包括两个子集（在Fi（O）调整之前和之后20分钟），并且包含呼吸机设置，pH和动脉血气值。我们使用新公式（仅利用调整前Pa（O）和调整前和调整后Fi（O）与使用恒定Pa（O）/ Fi（ O）或恒定的Pa（O）/ Pa（O）。随后，有20位临床医生使用新公式并使用Nunn的isoshunt图预测了Pa（O），并检验了临床医生预测的准确性。结果：一致度的95％患者组中预测和测量的Pa（O）之间的（LA（95％））为：新公式0.11（2.0）kPa，Pa（O）/ Fi（O）-1.9（4.4）kPa和Pa（O） / Pa（O）-1.0（3.6）kPa。临床医生对Pa（O）的预测的LA（95％）为0.56（3.6）kPa（新公式）和-2.7（6.4）kPa（等分线图）。 ：新公式对Pa（O）变化的预测是可以接受的准确，可靠且优于其他任何现有方法，临床医生使用它似乎比最流行的现有方法提高了准确度，该新方法的简单性可能允许其常规使用用于 重症监护环境。

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