Synthesis and Biological Evaluation of N-Aryl-N '-(5-(2-hydroxybenzoyl)pyrimidin-2-yl)guanidines as Toll-Like Receptor 4 Antagonists

Sova Matej; Rozman Kaja; Svajger Urban; Rozman Primoz; Gobec Stanislav

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Synthesis and Biological Evaluation of N-Aryl-N '-(5-(2-hydroxybenzoyl)pyrimidin-2-yl)guanidines as Toll-Like Receptor 4 Antagonists

机译：N-芳基-N'-（5-（2-（2-羟基苯甲酰基）嘧啶-2-基）胍作为Toll样受体4拮抗剂的合成及生物学评价

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Background: Toll-like receptor 4 (TLR4) has been associated with several inflammatory diseases, such as sepsis, atherosclerosis and chronic pain.

机译：背景：Toll样受体4（TLR4）与几种炎性疾病有关，例如败血症，动脉粥样硬化和慢性疼痛。

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来源
《Medicinal chemistry》 |2016年第8期|共9页
作者
Sova Matej; Rozman Kaja; Svajger Urban; Rozman Primoz; Gobec Stanislav;
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原文格式 PDF
正文语种 eng
中图分类医用化学;
关键词
Formylchromones; pyrimidines; cyanamides; guanidines; microwave-assisted synthesis; Toll-like receptor ligands;

机译：甲酰色酮;嘧啶;氰胺;胍;微波辅助合成;Toll样受体配体;

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1. Synthesis and Biological Evaluation of N-Aryl-N '-(5-(2-hydroxybenzoyl)pyrimidin-2-yl)guanidines as Toll-Like Receptor 4 Antagonists [J] . Sova Matej, Rozman Kaja, Svajger Urban, Medicinal chemistry . 2016,第8期

机译：N-芳基-N'-（5-（2-（2-羟基苯甲酰基）嘧啶-2-基）胍作为Toll样受体4拮抗剂的合成及生物学评价
2. Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9 [J] . Daqing Wang, Dong Yu, Ekambar R. Kandimalla, Nucleic acids research . 2013,第6期

机译：Toll样受体7、8和9的新型拮抗剂化合物的设计，合成和生物学评估
3. Synthesis and Biological Evaluation of N-(5-(2,5-dimethyl-phenoxy)-2,2dimethylpentyl)-benzamide Derivatives as Novel Farnesoid X Receptor (FXR) Antagonist [J] . Nian Siyun, Yu Zhenpeng, Tan Xiangduan, Letters in drug design & discovery . 2018,第9期

机译：N-（5-（2,5-二甲基 - 苯氧基）-2,2二甲基戊基） - 苄酰胺衍生物作为新型法呢X受体（FXR）拮抗剂的合成及生物学评价
4. Design and synthesis of bifunctional peptides:antagonists at CCKA/CCKB receptors and agonists as mu/delta opioid receptors [C] . Richard S.Agnes, Yeon Sun Lee, Peg Davis, the International Peptide Symposium . 2001

机译：双官能肽的设计与合成：Ccka / Cckb受体的拮抗剂和穆/δ阿片受体的激动剂
5. Synthesis and biological evaluation of conformationally constrained sphingosine-1-phosphate analogs as subtype selective S1P receptor agonist/antagonist. [D] . Zhu, Ran. 2008

机译：构象受限的鞘氨醇-1-磷酸类似物作为亚型选择性S1P受体激动剂/拮抗剂的合成和生物学评估。
6. Design synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7 8 and 9 [O] . Ekambar R. Kandimalla, Lakshmi Bhagat, Daqing Wang, 2013

机译：Toll样受体7、8和9的新型拮抗剂化合物的设计合成和生物学评估
7. Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9 [O] . Ekambar R. Kandimalla, Lakshmi Bhagat, Daqing Wang, 2013

机译：关于抗旱性受体7,8和9的新型拮抗剂化合物的设计，合成和生物学评价

Synthesis and Biological Evaluation of N-Aryl-N '-(5-(2-hydroxybenzoyl)pyrimidin-2-yl)guanidines as Toll-Like Receptor 4 Antagonists

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