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首页> 外文期刊>Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents >Anti-inflammatory and analgesic activities of a new cucurbitacin isolated from Citrullus colocynthis seeds
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Anti-inflammatory and analgesic activities of a new cucurbitacin isolated from Citrullus colocynthis seeds

机译：从瓜瓜种子中分离得到的新葫芦素的抗炎和镇痛作用

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Current study was designed to explore the analgesic and the anti-inflammatory activities of a new cucurbitacin isolated from Tunisian Citrullus colocynthis Schrad. seeds. 11-Deoxocucurbitacin-I-2-O-beta-D-glucoside was isolated from C. colocynthis seed chloroform fraction. This organic fraction, one of its subfraction (F19), and the purified 11-deoxocucurbitacin-I-2-O-beta-D-glucoside were investigated for anti-inflammatory activity using carra-geenan-induced paw edema assay in rats at the doses of 0.5 and 1 mg/kg body wt for the chloroform fraction and of 0.1 and 0.5 mg/kg body wt for the F19 subfraction and the purified product. For analgesic activity of different samples, the acetic acid and the phenylbenzoquinone writhing tests in mice were used at doses of 0.05, 0.1, and 0.5 mg/kg body wt. The results revealed that the seed chloroform fraction, the F19 subfraction, and the 11-deoxocucurbitacin-I-2-O-beta-D-glucoside exerted significant in vivo anti-inflammatory and analgesic activities at all tested doses.These results suggest that 11-deoxocucurbitacin-I-2-O-beta-D-glucoside from C. colocynthis seeds possessed potential pharmacological values and could be further investigated for its design as a new lead compound for management of pain and inflammation.
机译：当前的研究旨在探讨从突尼斯产柑桔（Citrullus colocynthis Schrad）分离出的一种新葫芦素的镇痛和抗炎活性。种子。从异纤梭菌种子氯仿级分中分离出11-脱氧葫芦素-I-2-O-β-D-葡萄糖苷。该有机级分（其子级分之一（F19））和纯化的11-脱氧葫芦素-I-2-O-β-D-葡糖苷在卡拉奇大鼠中通过卡拉南诱导的爪水肿试验研究了抗炎活性。对于氯仿馏分，剂量为0.5和1 mg / kg体重;对于F19馏分和纯化产品，剂量为0.1和0.5 mg / kg体重。对于不同样品的镇痛活性，以0.05、0.1和0.5 mg / kg体重的剂量使用小鼠体内的乙酸和苯基苯醌扭曲试验。结果表明，在所有测试剂量下，种子氯仿组分，F19组分和11-脱氧葫芦素-I-2-O-β-D-葡萄糖苷均具有显着的体内抗炎和镇痛活性。这些结果表明11虎尾草种子中的-deoxocucurbitacin-I-2-O-beta-D-D-糖苷具有潜在的药理学价值，可以作为设计用于治疗疼痛和炎症的新先导化合物进行进一步研究。

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