DNA-Binding Small Molecules as Inhibitors of Transcription Factors

LeungC.-H.; ChanD.S.-H.; MaV.P.-Y.; MaD.-L.

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DNA-Binding Small Molecules as Inhibitors of Transcription Factors

机译：DNA结合小分子作为转录因子的抑制剂。

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Accumulating evidence implicating the role of aberrant transcription factor signaling in the pathogenesis of various human diseases such as cancer and inflammation has stimulated the development of small molecule ligands capable of targeting transcription factor activity and modulating gene expression. The use of DNA-binding small molecules to selectively inhibit transcription factor-DNA interactions represents one possible approach toward this goal. In this review, we summarize the development of DNA-binding small molecule inhibitors of transcription factors from 2004 to 2011, and their binding mode and therapeutic potential will be discussed.

机译：越来越多的证据表明异常转录因子信号传导在各种人类疾病（例如癌症和炎症）的发病机理中的作用，已经刺激了能够靶向转录因子活性和调节基因表达的小分子配体的发展。使用DNA结合小分子选择性抑制转录因子与DNA的相互作用代表了实现这一目标的一种可能方法。在这篇综述中，我们总结了DNA结合小分子转录因子抑制剂从2004年到2011年的发展，并将讨论它们的结合方式和治疗潜力。

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来源
《Medicinal research reviews》 |2013年第4期|共24页
作者
LeungC.-H.; ChanD.S.-H.; MaV.P.-Y.; MaD.-L.;
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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Groove binding; Inhibitor; Intercalation; Small molecule; Transcription factor;

机译：沟槽结合抑制剂插层小分子转录因子;

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1. DNA-Binding Small Molecules as Inhibitors of Transcription Factors [J] . LeungC.-H., ChanD.S.-H., MaV.P.-Y., Medicinal research reviews . 2013,第4期

机译：DNA结合小分子作为转录因子的抑制剂。
2. SCH66336, inhibitor of protein farnesylation, blocks signal transducer and activators of transcription 3 signaling in lung cancer and interacts with a small molecule inhibitor of epidermal growth factor receptor/human epidermal growth factor receptor [J] . Dowlati A, Kluge A, Nethery D, Anti-cancer drugs . 2008,第1期

机译：SCH66336，蛋白法尼基化抑制剂，阻断肺癌中信号转导子和转录3信号激活剂，并与表皮生长因子受体/人表皮生长因子受体的小分子抑制剂相互作用
3. A small natural molecule CADPE kills residual colorectal cancer cells by inhibiting key transcription factors and translation initiation factors [J] . Guo-Wan Zheng, Ming-Min Tang, Chen-Yan Shu, Cell death & disease. . 2020,第11期

机译：小型天然分子CADPE通过抑制关键转录因子和翻译启动因子来杀死残留的结肠直肠癌细胞
4. Comprehensive analysis for the recognition sequences of DNA-binding transcription factors within the E. coli genome using the newly developed "Promoter Chip" [C] . Yamamoto Kaneyoshi, Shimada Tomohiro, Ishihama Akira International Symposium on Micro-NanoMechatronics and Human Science . 2008

机译：使用新开发的“启动子芯片”的大肠杆菌基因组中DNA结合转录因子识别序列的综合分析
5. A Bioinformatic Investigation of Off-Target Binding Events of Engineered DNA-Binding Proteins and Applications of Artificial Transcription Factors for Malaria Research. [D] . Yu, Abigail Stephanie. 2015

机译：工程脱氧核糖核酸结合蛋白的脱靶结合事件的生物信息学研究和人工转录因子在疟疾研究中的应用。
6. Raf Kinase Inhibitor Protein (RKIP) Inhibits Tumor Necrosis Factor-α (TNF-α) Induced Adhesion Molecules Expression in Vascular Smooth Muscle Bells by Suppressing (Nuclear Transcription Factor-κB (NF-kappaB) Pathway [O] . Shen-Hong Jing, Xuan Gao, Bo Yu, 2017

机译：Raf激酶抑制剂蛋白（RKIP）通过抑制（核转录因子-κB（NF-kappaB）途径抑制肿瘤坏死因子-α（TNF-α）诱导的血管平滑肌铃中的粘附分子表达。
7. Specific Pax-6/Microphthalmia Transcription Factor Interactions Involve Their DNA-binding Domains and Inhibit Transcriptional Properties of Both Proteins [O] . Nathalie Planque, Laurence Leconte, Frédéric M. Coquelle, 2001

机译：特异性pax-6 /微蛋白转录因子相互作用涉及其DNA结合结构域并抑制两种蛋白质的转录性质

DNA-Binding Small Molecules as Inhibitors of Transcription Factors

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