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首页> 外文期刊>Medicine. >Serotype 6B from a pneumococcal polysaccharide vaccine induces cross-functional antibody responses in adults to serotypes 6A, 6C, and 6D
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Serotype 6B from a pneumococcal polysaccharide vaccine induces cross-functional antibody responses in adults to serotypes 6A, 6C, and 6D

机译：来自肺炎球菌多糖疫苗的血清型6B在成年人中诱导对血清型6A，6C和6D的跨功能抗体应答

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Cross-reactivity of pneumococcal capsular polysaccharides is a key element for formulating pneumococcal vaccines and evaluating vaccine efficacy. This study examined whether 23-valent pneumococcal polysaccharide vaccine (PPSV23), which only contains 6B, can elicit cross-functional immune responses against recently discovered serotypes (6C and 6D), as well as against 6A, in 2 adult age groups.Young adults (25-51 years; N=28) and elderly subjects (over 65 years; N=60) were immunized with PPSV23. Functional antibody responses were determined in pre- and postimmune sera via multiplexed opsonophagocytic killing assay against serotypes 6A/B/C/D.At postimmunization, the geometric mean opsonic indices (OIs) for 6B and nonvaccine serotypes (6A, 6C, and 6D) significantly increased in both age groups. The geometric fold increases of OIs for 6B/A/C/D significantly differed (18.2, 24.8, 3.1, and 7.1, respectively). Proportions of subjects with 4-fold increases in OIs for 6B/A/C/D were 73%, 70%, 31%, and 49%, respectively. Correlations of fold increases in OIs were highest between 6B and 6A, followed by 6B and 6D, then by 6B and 6C. Comparisons of young adults and the elderly revealed that most immunogenicity variables were higher in the former group.Our data demonstrated that 6B in PPSV23 induced cross-functional immune responses against serotypes 6A, 6C, and 6D, according to the degree of similarity in their capsular polysaccharide structures. In addition, we found significant age-related differences in PPSV23-induced cross-reactivity.
机译：肺炎球菌荚膜多糖的交叉反应性是配制肺炎球菌疫苗和评估疫苗功效的关键要素。这项研究检查了仅包含6B的23价肺炎球菌多糖疫苗（PPSV23）是否可以在2个成年年龄组中引发针对最近发现的血清型（6C和6D）以及针对6A的跨功能免疫反应。 （25-51岁; N = 28）和老年受试者（65岁以上; N = 60）用PPSV23免疫。通过针对6A / B / C / D血清型的多重调理吞噬杀伤试验在免疫前和免疫后血清中确定功能性抗体应答。免疫后，针对6B和非疫苗血清型（6A，6C和6D）的几何平均调理指数（OI）在两个年龄段中均明显增加。 6B / A / C / D的OI的几何倍数增加显着不同（分别为18.2、24.8、3.1和7.1）。 OIs在6B / A / C / D中增加4倍的受试者的比例分别为73％，70％，31％和49％。 OI倍数增加的相关性在6B和6A之间最高，其次是6B和6D，然后是6B和6C。年轻人和老年人的比较显示，前一组中大多数免疫原性变量较高。我们的数据表明，PPSV23中的6B根据荚膜的相似程度诱导针对血清型6A，6C和6D的跨功能免疫应答。多糖结构。此外，我们在PPSV23诱导的交叉反应中发现了明显的年龄相关差异。

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