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Shiga toxin-producing E. coli - the actual state of knowledge.

机译:产生志贺毒素的大肠杆菌-实际情况。

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For the last 25 years, Shiga toxin producing E. coli (STEC) have been a serious cause of human diseases, responsible for the progression of haemorrhagic colitis (HC), haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Cattle and other ruminants are the main reservoirs of these bacteria. The infections are mainly associated with strains belonging to serogroups O157, O26, O103, O111 and O113. The main source of the bacteria is contaminated food of animal origin (especially beet) but water and person to person transmission may play a significant role in human infections. Large outbreaks connected to STEC can be transmitted to many people causing serious morbidity and mortality, making this bacteria one of the most significant foodborne pathogens. In this paper several plasmid and chromosomal genes responsible for the expression of important virulence determinants of STEC have been described. Among them, Shiga toxin (Stx) encoded by the stx genes is the best characterized pathogenic marker. This review focused on improving the knowledge of STEC and the function of the virulence markers, it is recommended that further studies are needed to evaluate the role of STEC genes in e.g. apoptosis or quorum sensing processes..
机译:在过去的25年中,产生志贺毒素的大肠杆菌(STEC)一直是人类疾病的严重病因,导致了出血性结肠炎(HC),溶血性尿毒症候群(HUS)和血栓性血小板减少性紫癜(TTP)的发展。牛和其他反刍动物是这些细菌的主要贮藏库。感染主要与属于血清群O157,O26,O103,O111和O113的菌株有关。细菌的主要来源是受动物污染的食物(特别是甜菜),但水和人与人之间的传播可能在人类感染中起重要作用。与STEC相关的大规模暴发可传播给许多人,从而导致严重的发病率和死亡率,使该细菌成为最重要的食源性病原体之一。在本文中,已经描述了负责STEC重要毒力决定子表达的几种质粒和染色体基因。其中,由stx基因编码的志贺毒素(Stx)是最能表征的致病标记。这篇综述着重于提高STEC的知识和毒力标记的功能,建议需要进一步的研究来评估STEC基因在例如大肠杆菌中的作用。细胞凋亡或群体感应过程

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