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首页> 外文期刊>Mathematical Biosciences: An International Journal >Predicting stability of mixed microbial cultures from single species experiments: 2. Physiological model
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Predicting stability of mixed microbial cultures from single species experiments: 2. Physiological model

机译:通过单一物种实验预测混合微生物培养物的稳定性:2.生理模型

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In this paper.. we study the equilibria of a physiological model describing the continuous culture in which two microbial populations compete for two substitutable resources. This work is an extension of the stability analysis of the phenomenological model of mixed microbial growth [M.M. Ballyk, G.S.K. Wolkowicz, Exploitative competition in the chemostat for two perfectly substitutable resources, Math. Biosci. 118 (1993) 127-180; S.S. Pilyugin, G.T. Reeves, A. Narang, Predicting stability of mixed microbial cultures from single species experiments: 2. Phenomenological model]. Here, we investigate the influence of the peripheral enzymes that catabolize the substrate uptake on the stability of the mixed culture. We show that, under steady state conditions, an increase in the concentration of one substrate inhibits the uptake of the other substrate(s). We present the criteria for existence, uniqueness, and stability of various types of equilibria. We formulate these criteria in terms of growth isoclines and consumption curves for each of the competing species. Since both types of curves can be obtained from a single species experiment, our approach provides a direct connection between theory and experiment and allows one to infer the dynamics of mixed cultures from the dynamics of single species cultures. By expressing the stability criteria in terms of intracellular properties, the model establishes a link between ecology and molecular biology. (C) 2004 Elsevier Inc. All rights reserved.
机译:在本文中,我们研究了描述两个微生物种群竞争两种可替代资源的连续培养的生理模型的平衡性。这项工作是对混合微生物生长现象学模型的稳定性分析的扩展。巴利克(G.S.K.) Wolkowicz,在Chemostat中进行的两个完全可替代资源Math的开发性竞争。生物科学。 118(1993)127-180; S.S. Pilyugin,G.T. Reeves,A。Narang,从单一物种实验预测混合微生物培养物的稳定性:2.现象学模型]。在这里,我们研究了分解底物吸收的外围酶对混合培养物稳定性的影响。我们表明,在稳态条件下,一种底物浓度的增加会抑制其他底物的吸收。我们提出了各种平衡类型的存在,唯一性和稳定性的标准。我们根据生长曲线和每个竞争物种的消耗曲线来制定这些标准。由于可以从单个物种的实验中获得两种类型的曲线,因此我们的方法在理论和实验之间提供了直接的联系,并允许人们从单个物种的培养动力学中推断出混合培养的动力学。通过表达细胞内特性的稳定性标准,该模型在生态学和分子生物学之间建立了联系。 (C)2004 Elsevier Inc.保留所有权利。

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