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首页> 外文期刊>Mathematical Biosciences: An International Journal >Tumour eradication by antiangiogenic therapy: analysis and extensions of the model by Hahnfeldt et al. (1999)
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Tumour eradication by antiangiogenic therapy: analysis and extensions of the model by Hahnfeldt et al. (1999)

机译:通过抗血管生成疗法根除肿瘤:Hahnfeldt等人对该模型的分析和扩展。 (1999年)

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摘要

The model proposed by Hahnfeldt et al. (1999) describes the growth of a tumour assuming that tumour growth is strictly controlled by the evolution of the vascular network that supplies oxygen and nutrients to tumour cells. Consequently, it provides a framework to represent the effects of antiangiogenic therapies. In this paper, some possible modifications of that model are proposed, and conditions that guarantee the eradication of the tumour under a regimen of periodic antiangiogenic therapy are derived. The model variants considered assume the potential doubling time of the vasculature to be constant, and subdivide the endothelial cell pool, which is involved in angiogenesis, in resting and proliferating cells allowing for a more detailed description of drug effects. (C) 2004 Elsevier Inc. All rights reserved.
机译:Hahnfeldt等人提出的模型。 (1999)描述了肿瘤的生长,假设肿瘤的生长受到血管网络的严格控制,血管网络向肿瘤细胞提供氧气和营养。因此,它提供了代表抗血管生成疗法效果的框架。在本文中,提出了对该模型的一些可能的修改,并推导了保证在定期抗血管生成治疗方案下根除肿瘤的条件。考虑的模型变体假设脉管系统的潜在倍增时间恒定,并细分静息和增殖细胞中涉及血管生成的内皮细胞库,从而可以更详细地描述药物作用。 (C)2004 Elsevier Inc.保留所有权利。

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