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首页> 外文期刊>Metabolism: Clinical and Experimental >Adding exercise to rosuvastatin treatment: influence on C-reactive protein, monocyte toll-like receptor 4 expression, and inflammatory monocyte (CD14+CD16+) population.
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Adding exercise to rosuvastatin treatment: influence on C-reactive protein, monocyte toll-like receptor 4 expression, and inflammatory monocyte (CD14+CD16+) population.

机译：罗苏伐他汀治疗中增加锻炼：对C反应蛋白，单核细胞toll样受体4表达和炎性单核细胞（CD14 + CD16 +）群体的影响。

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摘要

Statin treatment and exercise training can reduce markers of inflammation when administered separately. The purpose of this study was to determine the effect of rosuvastatin treatment and the addition of exercise training on circulating markers of inflammation including C-reactive protein (CRP), monocyte toll-like receptor 4 (TLR4) expression, and CD14+CD16+ monocyte population size. Thirty-three hypercholesterolemic and physically inactive subjects were randomly assigned to rosuvastatin (R) or rosuvastatin/exercise (RE) groups. A third group of physically active hypercholesterolemic subjects served as a control (AC). The R and RE groups received rosuvastatin treatment (10 mg/d) for 20 weeks. From week 10 to week 20, the RE group also participated in an exercise training program (3d/wk). Measurements were made at baseline (Pre), week 10 (Mid), and week 20 (Post), and included TLR4 expression on CD14+ monocytes and CD14+CD16+ monocyte population size as determined by 3-color flow cytometry. Serum CRP was quantified by enzyme-linked immunosorbent assay. TLR4 expression on CD14+ monocytes was higher in the R group at week 20. When treatment groups (R and RE) were combined, serum CRP was lower across time. Furthermore, serum CRP and inflammatory monocyte population size were lower in the RE group compared with the R group at the Post time point. When all groups (R, RE, and AC) were combined, TLR4 expression was greater on inflammatory monocytes (CD14+CD16+) compared with classic monocytes (CD14+CD16) at all time points. In conclusion, rosuvastatin may influence monocyte inflammatory response by increasing TLR4 expression on circulating monocytes. The addition of exercise training to rosuvastatin treatment further lowered CRP and reduced the size of the inflammatory monocyte population, suggesting an additive anti-inflammatory effect of exercise.
机译：单独应用他汀类药物治疗和运动训练可减少炎症标记。这项研究的目的是确定罗苏伐他汀治疗和运动训练对炎症循环标志物的影响，包括C反应蛋白（CRP），单核细胞toll样受体4（TLR4）表达和CD14 + CD16 +单核细胞数量尺寸。将33名高胆固醇血症和身体不活动的受试者随机分为瑞舒伐他汀（R）或瑞舒伐他汀/运动（RE）组。第三组身体活动的高胆固醇血症受试者作为对照（AC）。 R和RE组接受瑞舒伐他汀治疗（10 mg / d）20周。从第10周到第20周，RE组还参加了运动训练计划（3d / wk）。在基线（前），第10周（中）和第20周（后）进行测量，并包括通过三色流式细胞术测定的CD14 +单核细胞上TLR4表达和CD14 + CD16 +单核细胞群体大小。通过酶联免疫吸附测定法定量血清CRP。 R组在第20周时CD14 +单核细胞上TLR4的表达较高。当治疗组（R和RE）合并使用时，血清CRP随时间降低。此外，在Post时间点，RE组的血清CRP和炎性单核细胞群大小低于R组。当所有组（R，RE和AC）组合在一起时，在所有时间点上，炎性单核细胞（CD14 + CD16 +）上的TLR4表达要比经典单核细胞（CD14 + CD16）高。总之，罗苏伐他汀可能通过增加循环单核细胞上TLR4的表达来影响单核细胞的炎症反应。在瑞舒伐他汀治疗中增加运动训练可进一步降低CRP并减少炎性单核细胞群的大小，表明运动具有累加的抗炎作用。

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