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首页> 外文期刊>Metabolism: Clinical and Experimental >Effects of acute caloric restriction compared to caloric balance on the temporal response of the IGF-I system
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Effects of acute caloric restriction compared to caloric balance on the temporal response of the IGF-I system

机译：与热量平衡相比，急性热量限制对IGF-I系统时间反应的影响

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Objective: Insulin-like growth factor-I (IGF-I) is a key regulator of metabolism during altered energy states. The IGF-I system components respond to prolonged caloric restriction but it is not clear if this system responds similarly to acute caloric restriction. The purpose of this study was to characterize the IGF-I system response to acute caloric restriction with a secondary purpose of determining if two isocaloric diets with different ratios of carbohydrate to fat alter the IGF-I system under conditions of caloric balance. Materials/Methods: A double-blind, placebo-controlled crossover design was used in which 27 subjects underwent three, 48-h experimental treatments: 1) caloric restriction 2) carbohydrate and 3) carbohydrate/fat. Blood was sampled periodically (6 time points total) for IGF-I (total and free), IGFBPs1-4, insulin and glucose. ANOVAs were used with significance set at P < 0.05. Results: Total IGF-I decreased 7% during CR (P = 0.051) and remained stable during CHO and CHO/F. Free IGF-I decreased 43% during CR (P < 0.05) and remained stable during CHO and CHO/F. IGFBP-1 increased by 445% during CR (P < 0.05) compared to CHO and CHO/F with no changes for IGFBP-2, IGFBP-3 and IGFBP-4. There was no change in glucose or insulin during CR over the course of the study. Insulin and glucose increased (P < 0.05) after a meal in both the CHO and CHO/F groups with no difference between these two groups. Conclusion: Our findings indicate that free IGF-I decreases and IGFBP-1 increases during caloric restriction, but they are not altered with diets differing in carbohydrate and fat content. Changes in free IGF-I and IGFBP-1 are sensitive to caloric restriction, and their measurement may be valuable in monitoring the physiological response to refeeding in those consuming suboptimal calories.
机译：目的：胰岛素样生长因子-I（IGF-I）是能量状态改变期间新陈代谢的关键调节剂。 IGF-I系统的组成部分对长期的热量限制反应，但尚不清楚该系统是否对急性的热量限制做出类似反应。这项研究的目的是表征IGF-I系统对急性热量限制的反应，其次要目的是确定在热量平衡条件下，两种碳水化合物和脂肪比例不同的等热量饮食是否会改变IGF-I系统。材料/方法：采用双盲，安慰剂对照的交叉设计，其中27位受试者接受了3个48小时的实验处理：1）热量限制2）碳水化合物和3）碳水化合物/脂肪。定期采样血液（总共6个时间点）以获取IGF-1（总计和游离），IGFBPs1-4，胰岛素和葡萄糖。使用方差分析将显着性设置为P <0.05。结果：总的IGF-I在CR期间降低了7％（P = 0.051），并在CHO和CHO / F期间保持稳定。游离IGF-I在CR期间降低了43％（P <0.05），并在CHO和CHO / F期间保持稳定。与CHO和CHO / F相比，CR过程中IGFBP-1增加了445％（P <0.05），而IGFBP-2，IGFBP-3和IGFBP-4没有变化。在研究过程中，CR期间葡萄糖或胰岛素没有变化。 CHO和CHO / F组的餐后胰岛素和葡萄糖均增加（P <0.05），两组之间无差异。结论：我们的研究结果表明，热量限制期间，游离IGF-I降低而IGFBP-1升高，但碳水化合物和脂肪含量不同的饮食并没有改变它们。游离IGF-1和IGFBP-1的变化对热量限制很敏感，它们的测量值可能对监测那些摄入次优卡路里的人对补料的生理反应很有价值。

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