Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.

Lin HK; Yeh S; Kang HYChang C

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Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.

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Whereas several apoptosis-related proteins have been linked to the antiapoptotic effects of Akt serine-threonine kinase, the search continues to explain the Akt signaling role in promoting cell survival via antiapoptotic effects. Here, we demonstrate that Akt phosphorylates the androgen receptor (AR) at Ser-210 and Ser-790. A mutation at AR Ser-210 results in the reversal of Akt-mediated suppression of AR transactivation. Activation of the phosphatidylinositol-3-OH kinase/Akt pathway results in the suppression of AR target genes, such as p21, and the decrease of androgen/AR-mediated apoptosis, which may involve the inhibition of interaction between AR and AR coregulators. Together, these findings provide a molecular basis for cross-talk between two signaling pathways at the level of Akt and AR-AR coregulators that may help us to better understand the roles of Akt in the androgen/AR-mediated apoptosis.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2001年第13期|7200-7205|共6页
作者
Lin HK; Yeh S; Kang HYChang C;
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作者单位

George Whipple Laboratory for Cancer Research, Department of Pathology, and The Cancer Center, University of Rochester, Rochester, NY 14642, USA.;

op.uky.edu;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Apoptosis; Protein-Serine-Threonine Kinases; Proto-Oncogene Proteins; Receptors; Androgen; 脱噬作用; 蛋白质丝氨酸苏氨酸激酶; 原癌基因蛋白质类; 受体; 雄激素; 雄诺龙;

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Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.

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