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首页> 外文期刊>Cancer causes and control: CCC >Reduction of hepatocellular carcinoma in childhood after introduction of selective vaccination against hepatitis B virus for infants born to HBV carrier mothers.
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Reduction of hepatocellular carcinoma in childhood after introduction of selective vaccination against hepatitis B virus for infants born to HBV carrier mothers.

机译：在为乙肝病毒携带者母亲所生的婴儿引入针对乙肝病毒的选择性疫苗接种后，减少儿童期肝细胞癌的发生。

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OBJECTIVE: A nation-wide prevention program utilizing passive-active immunoprophylaxis for high-risk babies against maternal HBV transmission was introduced in Japan in January of 1986. The prevention program was expected to eradicate HBV-related hepatocellular carcinoma (HCC). The aim of this study was to evaluate the effect of this selective prevention program against maternal HBV transmission on the occurrence of HBV-related HCC. METHODS: We reviewed the annual reports from a nation-wide survey of childhood solid tumors that was reported in the Journal of the Japanese Society of Pediatric Surgeons during the 28 years period from 1981 to 2008. The number of HCC cases were grouped for every 5-year period with an additional period of the past 3 years and compared with those of hepatoblastoma. RESULTS: The reported number of children with hepatoblastoma in each period was constant during the 28 years study period. In contrast, both the number of patients with HBV-related HCC and the ratio of HBV-related HCC to hepatoblastoma gradually decreased over the study period, with a significant drop in the last two periods ranging from 2001 to 2008 (p < 0.001). CONCLUSION: The prevention program against maternal HBV infection of infants born to HBV carrier mothers may have decreased the occurrence of HBV-related HCC in childhood.
机译：目的：1986年1月，日本在全国范围内采用被动主动免疫预防高危婴儿预防母体HBV传播的预防方案。该预防方案有望根除HBV相关的肝细胞癌（HCC）。这项研究的目的是评估针对母体HBV传播的选择性预防计划对HBV相关HCC发生的影响。方法：我们回顾了1981年至2008年的28年间在《日本小儿外科医师杂志》上报道的全国性儿童期实体瘤调查的年度报告。每5例HCC病例数分组年期和过去3年的额外期，并与肝母细胞瘤进行比较。结果：在28年的研究期内，每个时期报告的肝母细胞瘤儿童数量均保持不变。相反，在研究期间，HBV相关性HCC的患者人数和HBV相关性HCC与肝母细胞瘤的比率均逐渐下降，在从2001年至2008年的最近两个期间均显着下降（p <0.001）。结论：预防由HBV携带者母亲所生婴儿的母亲HBV感染预防方案可能减少了儿童时期HBV相关HCC的发生。

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