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首页> 外文期刊>Cancer causes and control: CCC >Mammographic breast density and breast cancer risk by menopausal status, postmenopausal hormone use and a family history of breast cancer
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Mammographic breast density and breast cancer risk by menopausal status, postmenopausal hormone use and a family history of breast cancer

机译：乳房X光检查乳房密度和更年期状态，绝经后激素使用和乳腺癌家族史的乳腺癌风险

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Purpose Few studies have investigated the association between breast density and breast cancer by a family history of breast cancer, menopausal status, and postmenopausal hormone use (PMH). We investigated if associations of breast density and breast cancer differ according to the status of these risk factors. Methods This study included 1,481 incident breast cancer cases diagnosed within the Nurses' Health Study I and II cohorts and 2,779 matched controls. Breast density was measured from digitized film images with computerized techniques. Information on breast cancer risk factors was obtained prospectively from the biennial questionnaires before the date of the cancer diagnosis for cancer cases and their matched controls. The data were analyzed with logistic regression. Results Breast cancer risk increased with increasing percent breast density in all strata (p for trend in all subsets <0.0001). The density-related risk of breast cancer was similar in women with and without a family history (OR = 4.00 [95 % CI 2.01-7.94] vs. 3.71 [95 % CI 2.79-4.94] for density >50 % vs. <10 %, p for interaction = 0.53). The magnitude of the association between density and breast cancer risk, however, appeared to be stronger in premenopausal women than in postmenopausal women without PMH history (OR = 5.49 [95 % CI 2.44-12.39] vs. 3.02 [95 % CI 1.62-5.63] for density >50 %vs.<10 %,p-heterogeneity = 0.17) and appeared to be stronger in postmenopausal women currently using hormones compared with postmenopausal women who never used PMH (OR = 4.50 [95 % CI 2.99-6.78] vs. 3.02, p-heterogeneity = 0.20) or with past hormone use (OR = 4.50 vs. 3.71 [95 %CI 1.90-7.23],p-heterogeneity = 0.23). Conclusions Findings on associations by menopausal status/hormone use are suggestive and should be examined in additional larger studies.
机译：目的很少有研究通过乳腺癌家族史，绝经状态和绝经后激素使用（PMH）来研究乳腺密度与乳腺癌之间的关系。我们调查了根据这些危险因素的状况，乳房密度与乳腺癌的关联是否不同。方法该研究包括在“护士健康研究” I和II组中确诊的1,481例乳腺癌事件病例和2,779例匹配的对照。用计算机技术从数字化胶片图像中测量乳房密度。有关乳腺癌危险因素的信息可从癌症确诊日期之前的两年期调查表中获得，以了解癌症病例及其匹配的对照组。用逻辑回归分析数据。结果在所有阶层中，乳腺癌风险随乳房密度百分比的增加而增加（所有子集中趋势的p均<0.0001）。有和没有家族史的女性中与密度相关的乳腺癌风险相似（OR> 4.00 [95％CI 2.01-7.94]与3.71 [95％CI 2.79-4.94]，密度> 50％与<10 ％，相互作用的p = 0.53）。然而，绝经前女性的密度与乳腺癌风险之间的关联程度似乎强于无PMH病史的绝经后女性（OR = 5.49 [95％CI 2.44-12.39] vs. 3.02 [95％CI 1.62-5.63 ]密度> 50％vs。<10％，p-异质性= 0.17），与从未使用过PMH的绝经后女性相比，目前使用激素的绝经后女性似乎更强（OR = 4.50 [95％CI 2.99-6.78] vs 3.02，p-异质性= 0.20）或过去使用激素（OR = 4.50 vs. 3.71 [95％CI 1.90-7.23]，p-异质性= 0.23）。结论由更年期状态/激素使用引起的关联性发现具有启发性，应在其他大型研究中进行研究。

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